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An antigenic extract can be administered in a form and by a route which, rather than sensitize the recipient, may sometimes prolong the life of skin homografts.
"In addition," says Dr. Peter B. Medawar of the National Institute for Medical Research in London, "there is also evidence that antigen in a nonsensitizing form acts in synergism with several immunological depressants—X-rays, a-methopterin, and probably homologous isoantibody—to prolong the life of homografts." He reported his findings in the first issue of Transplantation.
He explained that the antigen used to produce tolerance has usually taken the form of a suspension containing viable donor cells. Since living cells normally sensitize adult recipients and so shorten the life of future homografts, "it is preferable to administer antigen in such a way that, while it retained the power to induce tolerance, it did not excite transplantation immunity. Also, the cells used to establish tolerance normally consist
Prolonging Skin Transplants With Antigenic Extract. JAMA. 1963;185(11):41. doi:10.1001/jama.1963.03060110021010
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