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October 19, 1963

Quantitative Approach to the I131 Renogram

Author Affiliations

Los Angeles

From the departments of radiology and preventive medicine and public health, University of California School of Medicine.

JAMA. 1963;186(3):211-214. doi:10.1001/jama.1963.03710030051008

Radioactive isotope renography has been a useful clinical procedure but, with only qualitative interpretation of the renogram, it is subject to diagnostic error. A statistical analysis of an approach to quantitation using the criteria of Tmax and T½ has been performed. With upper limits of normal set at 4 min and 7 min, respectively, for these criteria, 2 of 22 normal subjects showed false-positive results and 18 of 114 patients with proved renal disease had false-negative results. The analysis indicated that this simple and rapid quantitative approach led to a reasonable degree of accuracy.