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October 26, 1963

Peripheral and Autonomic Neuropathy in Amyloidosis: A Case Report

Author Affiliations

Madison, Wis.

From the departments of neurology and pathology, University of Wisconsin Medical Center.

JAMA. 1963;186(4):432-434. doi:10.1001/jama.1963.63710040011018d

RECENT MEDICAL LITERATURE contains many reports of cases of amyloidosis with a great variety of symptoms. Peripheral neuropathy and autonomic neuropathy have been mentioned in some articles,1-4 while others have stressed the presence of gastrointestinal symptoms. The most commonly occurring autonomic symptoms are alternating diarrhea and constipation, as well as sexual impotence.

Emphasis has been placed on the value of determining whether amyloidosis is of the secondary type (the type usually seen in association with chronic suppurative disease) or the primary type (a disease characterized by the deposition of amyloid in various tissues of the body with no known precipitating cause). In some instances it is difficult to determine whether two distinct diseases are present or whether both represent a spectrum of the same illness. It has also been noted that familial and nonfamilial forms of amyloidosis frequently run an identical course and show virtually the same findings when