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November 9, 1963

The Responses of Children to Combined Measles-Poliomyelitis Vaccine

Author Affiliations

Terre Haute, Ind; Syracuse, NY; New York; Denver; Terre Haute, Ind

From the Department of Biologics Research, Chas. Pfizer & Co., Inc., Terre Haute, Ind (Dr. Warren and Miss Gallian), State University of New York, Upstate Medical Center, Syracuse, NY (Dr. Feldman), Department of Clinical Research, Chas. Pfizer & Co., Inc., New York (Dr. Iezzoni), Department of Pediatrics, University of Colorado, Denver (Dr. Fulginiti), and Visiting Nurses' Association, Terre Haute, Ind (Dr. Conway).

JAMA. 1963;186(6):533-536. doi:10.1001/jama.1963.03710060019004

Vaccine combining inactivated, concentrated measles and poliovirus antigens was prepared and administered to children in 3 doses of 0.5 ml each, 1 month apart. The neutralizing antibody responses to both antigens were determined in a group of 133 persons. The combination vaccine produced as high a percentage and titer of seroconversions as did the individual antigens alone, appeared to be stable for prolonged periods, and caused only minimal reactions upon injection. Although positive seroconversions were less in infants under 4 months of age, combined measles and polio vaccines should be considered for augmenting diphtheria-pertussis-tetanus vaccine to confer basic primary sensitization in young children.