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November 9, 1963

Effect of Neutralizing Antibody on Experimental Rhinovirus Infection

Author Affiliations

Bethesda, Md; North Chicago, Ill; Bethesda, Md

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md (Drs. Mufson, Ludwig, and Chanock; Messrs. James and Gauld; and Mrs. Rourke); and Abbott Laboratories, North Chicago, Ill (Dr. Holper).

JAMA. 1963;186(6):578-584. doi:10.1001/jama.1963.63710060029013

RECENTLY an increasing number of viruses possessing common biological properties have been recovered from patients with minor respiratory illness. These agents have been variously named entero-like and enteroviruses,1 Salisbury viruses,2 coryzaviruses,3,4 and muriviruses.5 The Virus Subcommittee of the International Committee on the Nomenclature of Bacteria and Viruses designated the name "rhinoviruses" for these agents, and classified them as a subgroup of the picornaviruses.6 Unlike the enteroviruses, rhinoviruses are unstable in an acid solution (pH 3 to 5), and on this basis ECHO-28 has been reclassified among the rhinoviruses. At present the rhinovirus group appears to be composed of at least 30 antigenically distinct serotypes. Tyrrell has suggested that rhinoviruses which multiply in embryonic-human kidney cells, fetal-human diploid fibroblast cells, and primary monkey kidney cells be designated "M" strains, and those strains that propagate only in human cells be designated "H" strains.7

Recent epidemiological

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