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November 9, 1963

Hemolytic Anemia Secondary to Stibophen Therapy

JAMA. 1963;186(6):598-599. doi:10.1001/jama.1963.63710060044021b

STIBOPHEN (Fuadin) (sodium antimony III biscatechol-2-4 disulfonate heptahydrate), is an anthelmintic which since 1929 has been used extensively in the treatment of schistosomiasis. The manufacturers claim that toxicity is low and that severe side effects have not been observed. Transient nausea, vomiting, headache, diarrhea, and muscular and joint pains have been the most frequently observed side effects. Thrombocytopenia has been the most common hematological complication.1

In 1956 Harris2,3 described the occurrence of hemolytic anemia in a patient who was receiving stibophen therapy. Furthermore, he found that when stibophen was added to the patient's serum, antibodies active against cells from the patient and compatible red blood cells could be demonstrated. The patient had a positive direct and indirect Coombs' test.

In 1960, a similar case occurred but the antibodies appeared to be of the saline agglutinating type. During 1961, two cases of stibophen-induced hemolytic anemia came to our attention.