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November 9, 1963

Hypotension During Percutaneous Renal Biopsy

Author Affiliations

Palo Alto, Calif; Philadelphia

Instructor in Medicine, Stanford University School of Medicine, Palo Alto, Calif (Dr. Gardner); and Associate Professor of Medicine, University of Pennsylvania School of Medicine, Philadelphia, and John and Mary R. Markle Scholar in Medicine (Dr. Hildreth).

JAMA. 1963;186(6):599-600. doi:10.1001/jama.1963.63710060045021c

ON SEVERAL OCCASIONS during the past 5 years we have recorded the gradual appearance of hypotension in previously normotensive or mildly hypertensive patients undergoing percutaneous renal biopsy. Most of these hypotensive episodes have been mild and have not interfered with the biopsy routine which we usually follow.1 Those episodes of hypotension which we encountered early in our experience with percutaneous renal biopsy we attributed, in passing, to procaine hydrochloride sensitivity, to side-effects of the meperidine-secobarbital premedication, or to some influence of the patient's psyche on his vascular tone. As our biopsy experience has grown, however, we have found a more specific etiology for at least some of these episodes.

We have a combined percutaneous renal biopsy experience of over 800 cases. In this series we have encountered 15 individuals in whom systolic blood pressures have declined during biopsy to levels below 90 mm Hg (as low as 40 mm

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