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One of the problems confronting the pharmacologist is the question whether a given agent will enter the brain. This volume is an attempt to summarize the extensive studies of the author on the technique of intraventricular injection developed for the purpose of circumventing the problem of blood-brain permeability. A portion of the monograph is devoted to discussing the techniques and their rationale, while the major part deals with the various symptoms observed with a variety of autonomic and centrally active agents. Much of the work arising from the use of this technique has been widely criticized, and the author fails to allude either to its shortcomings or to the question of why much of the symptomatology is so different from what is observed when the given agent is administered systemically.
Leo G. Abood. A Pharmacological Approach to the Brain from its Inner and Outer Surface.. JAMA. 1963;186(6):614. doi:10.1001/jama.1963.03710060100037