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November 16, 1963

Atypical Sickle Cell Anemia

Author Affiliations


From the Department of Medicine, City of Detroit Receiving Hospital, and Wayne State University College of Medicine. Dr. Clifford is now at Memorial Hospital, New York.

JAMA. 1963;186(7):624-626. doi:10.1001/jama.1963.03710070026005

Four patients presenting unusual manifestations of sickle cell anemia were studied. Clinical variants were age, habitus, and pregnancy. In some cases, these features were so atypical as to suggest disease entities other than sickle cell anemia and obscure the diagnosis. The recognition of a wider clinical spectrum for occasional patients with this disease seems justified.