In review of experimental data on the use of sex steroids in cosmetics, there was evidence that some topically applied steroidal hormones, both active and inactive biologically, cause slight histological thickening of the epidermis of aged skin. Dermal changes are questionable and clinical effects usually negligible. In the amounts which can be safely incorporated into cosmetic preparations, topically applied estrogens have no effect on human sebaceous glands and oil secretion. Natural progesterone in physiological amounts causes no increase in oil secretion in the human. Used as directed, topically applied hormones as presently formulated in cosmetic preparations have adequate safety factors.
Strauss JS. Hormones in Cosmetics. JAMA. 1963;186(8):759–762. doi:10.1001/jama.1963.03710080031006
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