Author Affiliation: Dr Glass is Deputy Editor of JAMA.
Major depression is the fourth leading cause of worldwide disease
burden, according to a recent study of premature mortality and
disability around the world.1 The disease burden
attributable to unipolar major depression ranks after lower respiratory
tract infections, diarrheal diseases, and perinatal disorders, but
ahead of ischemic heart disease, cerebrovascular disease, and
tuberculosis.1 It is hard to imagine more compelling
evidence for the importance of diagnosing and treating depression
Glass RM. Treating Depression as a Recurrent or Chronic Disease. JAMA. 1999;281(1):83–84. doi:10.1001/jama.281.1.83
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