Up to this time eighteen cases of coccidioidal granuloma have been reported and traced to California, the seventeenth and eighteenth being reported by Brown1 of San Francisco, with review of the literature. The first case in California was discovered by Rixford2 of San Francisco, and later described in conjunction with Gilchrist3 of the Johns Hopkins Hospital Medical School. Afterward Ophüls4 of San Francisco described the fungus with certain morphology and characteristics, giving the name of Oidium coccidioides, with report of thirteen cases, differentiating the fungus from the closely related Blastomyces coccidioides of which much has been written, the latest article being by Hektoen5 of Chicago.
The mold appears to be of animal origin, though not proved, with occasional infection in man. Most infected persons came from the lower half of the San Joaquin valley, and were men employed in railway construction or in caring for
BOWLES FH. COCCIDIOIDAL GRANULOMA: REPORT OF THE NINETEENTH CASE IN CALIFORNIA. JAMA. 1912;LIX(25):2253. doi:10.1001/jama.1912.04270140057022
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