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April 26, 1890


JAMA. 1890;XIV(17):611-612. doi:10.1001/jama.1890.02410170019003

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Lead Poisoning.  Binet and Prévost have communicated to the Medical Society of Geneva the results of some very interesting researches on the subject of lead poisoning. Their conclusions are these: Animals poisoned by the daily ingestion of white lead presented the following symptoms: A progressive emaciation; anæmia from diminution and alteration of the blood globules, without leucocytosis; albuminuria, which, however, has been neither abundant nor constant; nervous phenomena—paralysis, aphonia, loss of reflexes, anæsthesia, rarely convulsions; the paralyses are curable when the lead is discontinued.The anatomical features are these: A constant alteration of the kidneys, which become grayish, contracted, often cystic; nephritis and a special form of calcareous granulation, according with the type described by Charcot and Gombaut; fatty degeneration of the liver; frequently pericarditis and sometimes granulo-fatty degeneration of the myocardium; lesions of the peripheral nerves of the segmentary type; the medullary roots are rarely affected; regeneration of

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