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The pathogenesis of diabetes mellitus has been a fertile field for speculation. Bouchard was able to count twenty-seven theories of the disease. Nearly all of these have been based upon the classic investigations of Claude-Bernard, on the formation and excretion of sugar in the body. Since the contributions of Bouchardat, the association of diseases in the pancreas with diabetes has been frequently noted; so that Senator assumes that pathological changes in the pancreas occur in about one-half of all cases of diabetes. Baumel maintains that disease of the pancreas is found in all cases; in the milder forms microscopical, in the more severe cases, gross, pathological changes are found. This frequency precludes the possibility of accidental association. According to the view of Klebs, lesions of the cœliac plexus are the cause of this association. Either the disease is primarily in the pancreas from whence it encroaches upon the plexus, or
KRAMER SP. RECENT INVESTIGATIONS ON THE ETIOLOGY OF DIABETES. JAMA. 1892;XIX(4):89–90. doi:10.1001/jama.1892.02420040001001
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