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J. N. O., age 66 years. One of a family of two children. Father and mother lived to the age respectively of 63 and 81. No recognized defect in the eyes of father or mother. Father afflicted with a contraction of the subcutaneous fascia of palm of the hand, resulting in the condition known as Dupuytrien's fingers. Patient's brother, now dead, was afflicted in a similar way in the right hand, but only one fingef was affected. Patient himself, who was for a great part of his life an English sailor, has marked, severe contraction of several fingers, involving both hands, clearly referable to similar condition of the subcutaneous fascia. He has now and has had for ten years at least, a remarkable intermittent pulse; remarkable in that there is a decided regularity to the irregularity. I took a tracing of it, but finding that it really failed to give