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The popular knowledge in regard to the new " gout-water," containing piperazine, is spreading, and laymen in the horse-cars have been overheard discussing the merits of the water. But it is not yet so widely understood that there are other forms of the drug in addition to the aqueous solution of the hygroscopic crystals: for example, the Notes on New Remedies in its Berlin letter, informs us that the chemists have been enabled to produce tablets of piperazine. These compressed tablets contain the ordinary daily dose of 15 grs. They are easily disintegrated and dissolved in water, a manifest convenience in the case of travelers and vacation seekers. A granular effervescing powder has also been produced: in this form, the drug is said to be more palatable—although the crystals should be nearly tasteless—and the patient is led to imbibe more freely of water than he otherwise would—a point which is helpful
PIPERAZINE IN GOUT.. JAMA. 1892;XIX(13):383. doi:10.1001/jama.1892.02420130027004
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