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October 1, 1892


JAMA. 1892;XIX(14):414-415. doi:10.1001/jama.1892.02420140028004

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A study of the principles of Darwinism would certainly lead one to expect some compensation for the entire loss or partial removal of any structure. As the presence of each structure depends upon necessity and as the loss of a structure implies absence of function, the demand for that function would require that it be replaced either through changes in similar structures remaining or in entirely diverse tissues. This compensation may be analyzed into these varieties: 1. Sufficient similar tissue still remains in the organism; there simply being increase in functional activity. 2. Numerical increase in the tissue elements remaining. 3. Volumetric increase of the remaining elements. 4. Production of similar tissue in other structures. 5. Assumption of the function by some entirely foreign structure. Of these divisions only the second and third permit of analysis as compensatory hypertrophy the others being purely compensations. It is then apparent that

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