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December 3, 1892


JAMA. 1892;XIX(23):676. doi:10.1001/jama.1892.02420230026004

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Dr. Renzi has given, in the Revista Clinica e Therapeutica, some facts regarding his new method of employing iodine in phthisical cases. His formula prescribes the use of iodine one part, iodide of potassium, three parts, chloride of sodium, six parts, and distilled water 1000 parts. He injected this solution into the ear-vein of healthy, and also diseased rabbits, and into the subcutaneous tissue of rabbits, guinea-pigs and dogs. Having in this manner carefully established the complete tolerance of the compound, he began to give it to his phthisical patients. Hypodermatic dosage was first tried with them, as much as 100 grains having been thus given. This method was not well borne, and the remedy was next tried by the mouth, the dose being from 500 to 550 grains. Nineteen patients, nearly all of them with advanced phthisis, were thus treated. Symptoms of iodism were produced in some patients, but

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