In 1890, at a time when little or nothing was known of the chemical constitution of the thyroid gland and when we were unaware that it possessed any particular therapeutic action, the writer offered the first experimental proof that the thyroid gland was in some manner concerned in the general metabolism of the organism.1 While even to-day we are not in possession of any positive proof of the true physiologic rôle of the thyroid gland, its action as a therapeutic agent, and further the clinical and experimental results following total extirpation along with the action of diet in various thyroid diseases and after total extirpation of this gland, indicates that it is in some manner invested with a metabolic function, but which we are not as yet able to particularly define. It would lead us too far were I to attempt to give a résumé
BREISACHER L. THE CLINICAL APPLICATION OF SOME THYROID GLAND EXPERIMENTS.. JAMA. 1903;XL(9):566–567. doi:10.1001/jama.1903.92490090014001e
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