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May 25, 2011

Mortality Risk Among Middle-aged Women With First Atrial Fibrillation

Author Affiliations

Author Affiliations: Cardiovascular Division, Department of Medicine II, Kansai Medical University, Hirakata, Japan (Dr Miyasaka); and Division of Cardiology, University of British Columbia, Vancouver, Canada (Dr Tsang).

JAMA. 2011;305(20):2116-2117. doi:10.1001/jama.2011.699

In this issue of JAMA, the report by Conen and colleagues1 provides further evidence to confirm an increased mortality risk among middle-aged women with new-onset atrial fibrillation (AF). The study cohort consisted of 34 722 health care professionals in the Women's Health Study (WHS) who agreed to prospective follow-up after the end of the randomized treatment trial. These women were aged 49 to 59 years and free of cardiovascular disease at baseline. During a median follow-up of 15.4 years, 1011 women (2.9%) developed new-onset AF, and 63 deaths occurred among these women. In multivariable models, incident AF was associated with an increased adjusted risk of all-cause mortality, as well as cardiovascular and noncardiovascular death.