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August 2, 2006

Maternal Famine, De Novo Mutations, and Schizophrenia

Author Affiliations

Author Affiliations: Department of Psychiatry, University of Washington, Seattle (Dr McClellan); Department of Epidemiology, Mailman School of Public Health, Columbia University, and New York State Psychiatric Institute, New York (Dr Susser); and Departments of Genome Sciences and Medicine (Medical Genetics), University of Washington, Seattle (Dr King).

JAMA. 2006;296(5):582-584. doi:10.1001/jama.296.5.582

Schizophrenia is a debilitating neuropsychiatric disorder that likely stems from multiple genetic and environmental factors.1 Identifying molecular mechanisms underlying schizophrenia offers the promise of improved treatment and prevention strategies. Finding culprit mutations and the genes that harbor them is therefore one of the great challenges of human genomics.