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November 22/29, 2022, Vol 328, No. 20, Pages 1993-2078

In This Issue of JAMA

Audio Highlights

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JAMA. 2022;328(20):e2117224. doi:10.1001/jama.2021.17224
Original Investigation

Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial

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JAMA. 2022;328(20):2022-2032. doi:10.1001/jama.2022.20206

This randomized clinical trial compares the effect of different doses (8 mg/d or 16 mg/d) of extended-release morphine vs placebo on chronic breathlessness in people with chronic obstructive pulmonary disease (COPD).

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021

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JAMA. 2022;328(20):2033-2040. doi:10.1001/jama.2022.20149

This cross-sectional study compares in-hospital mortality among patients with ST-segment elevation myocardial infarction receiving treatment within the US national guidelines–recommended target times vs later.

Estimated Travel Time and Spatial Access to Abortion Facilities in the US Before and After the Dobbs v Jackson Women’s Health Decision

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JAMA. 2022;328(20):2041-2047. doi:10.1001/jama.2022.20424

This cross-sectional spatial analysis examines travel time from each census tract in the contiguous US to the nearest abortion facility before and after the Dobbs v Jackson Women’s Health Organization US Supreme Court decision.

Association of Texas’ 2021 Ban on Abortion in Early Pregnancy With the Number of Facility-Based Abortions in Texas and Surrounding States

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JAMA. 2022;328(20):2048-2055. doi:10.1001/jama.2022.20423

This study assesses changes in the number of abortions and changes in the percentage of out-of-state abortions among Texas residents performed 12 or more weeks of gestation in the first six 6 months following implementation of a Texas senate bill prohibiting abortions after detection of embryonic cardiac activity.

Research Letter

Reported Awareness and Adoption of 2021 Estimated Glomerular Filtration Rate Equations Among US Clinical Laboratories, March 2022

Abstract Full Text
JAMA. 2022;328(20):2060-2062. doi:10.1001/jama.2022.15404

This study includes clinical laboratories that participated in the first general chemistry proficiency testing survey in 2022 to assess awareness and adoption of new equations from the Chronic Kidney Disease Epidemiology Collaboration for estimated glomerular filtration rate (eGFR) that eliminated race-adjustment factors, including one based on creatinine and one based on creatinine and cystatin C.

Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial

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JAMA. 2022;328(20):2062-2064. doi:10.1001/jama.2022.16476

This study examines adverse events and durability of response of SER-109, an investigational microbiome therapeutic comprised of purified Firmicutes spores, compared with placebo for Clostridioides difficile infection.

Human Monkeypox Virus Infection in the Immediate Period After Receiving Modified Vaccinia Ankara Vaccine

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JAMA. 2022;328(20):2064-2067. doi:10.1001/jama.2022.18320

This study uses electronic medical record data to describe monkeypox infections after a single dose of Modified Vaccinia Ankara-Bavarian Nordic vaccine, a live, nonreplicating vaccine indicated for prevention of smallpox and monkeypox infection in adults.

Viewpoint

Closing the Loophole on Hemp-Derived Cannabis Products: A Public Health Priority

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JAMA. 2022;328(20):2007-2008. doi:10.1001/jama.2022.20620

This Viewpoint discusses a federal policy loophole that allows psychotropic cannabis products to be commercially marketed and sold across the US, even in states where recreational cannabis is not legal.

The Tobacco Industry and Harm Reduction

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JAMA. 2022;328(20):2009-2010. doi:10.1001/jama.2022.20679

This Viewpoint discusses the ways in which the tobacco industry can advance their stated goals of harm reduction and a smoke-free future.

Implications of Dobbs for the (Re)Criminalization of Intimacy Among LGBTQ Individuals

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JAMA. 2022;328(20):2011-2012. doi:10.1001/jama.2022.20609

This Viewpoint outlines how the revival of now defunct state-level antisodomy laws would harm the health care of LGBTQ individuals should the US Supreme Court reverse itself and urges medical professionals and their societies to advocate for the immediate abolition of antisodomy laws.

A Piece of My Mind

Role Reversal

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JAMA. 2022;328(20):2013. doi:10.1001/jama.2022.20556

In this narrative essay, a medical student discusses how observing a patient interacting with her adult daughter was a reminder of the ways in which the roles will eventually be reversed in her relationship with her own young daughter.

Editorial

Dyspnea—When a Sensation Becomes a Symptom

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JAMA. 2022;328(20):2014-2015. doi:10.1001/jama.2022.19248

Time to Treatment in ST-Segment Elevation Myocardial Infarction: Identifying Dangerous Delays or Diminishing Returns?

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JAMA. 2022;328(20):2016-2017. doi:10.1001/jama.2022.19441

The International Code of Medical Ethics of the World Medical Association

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JAMA. 2022;328(20):2018-2021. doi:10.1001/jama.2022.19697
JAMA Clinical Guidelines Synopsis

Diagnosis and Treatment of Infertility in Men

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JAMA. 2022;328(20):2056-2057. doi:10.1001/jama.2022.19294

This article summarizes guidelines on identifying and addressing infertility in men from the American Urological Association and American Society for Reproductive Medicine.

JAMA Clinical Challenge

Intermittent Chest Pain in a 46-Year-Old Patient

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JAMA. 2022;328(20):2058-2059. doi:10.1001/jama.2022.19443

A patient in his 40s presented to the emergency department with chest pain and diaphoresis, which had also occurred 2 days earlier. He had a 20 pack-year history of smoking but no family history of cardiovascular disease. The patient’s electrocardiogram showed biphasic T waves in leads V2 and V3. What would you do next?

Medical News & Perspectives

After the First Pig-to-Human Heart Transplant, Scientists Look to the Future of Cardiac Xenotransplantation

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JAMA. 2022;328(20):1999-2001. doi:10.1001/jama.2022.15434

This Medical News article discusses how cardiac xenotransplantation with genetically modified pig hearts might help relieve the shortage of human donor hearts.

News From the Centers for Disease Control and Prevention

CDC Report: Urgent Need to Address Teens’ Adverse Experiences During Pandemic

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JAMA. 2022;328(20):2005. doi:10.1001/jama.2022.18488

Targeted Flu Vaccination Campaigns Needed for Certain Racial and Ethnic Groups

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JAMA. 2022;328(20):2005. doi:10.1001/jama.2022.18487
Clinical Trials Update

Financial Vouchers Led to Higher Smoking Abstinence During Pregnancy

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JAMA. 2022;328(20):2003. doi:10.1001/jama.2022.18484

Intranasal COVID-19 Vaccine Disappointing in First-in-Human Trial

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JAMA. 2022;328(20):2003. doi:10.1001/jama.2022.18485

Colonoscopy Did Not Reduce Cancer Deaths in Trial

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JAMA. 2022;328(20):2003-2004. doi:10.1001/jama.2022.18486

Shorter Duration of Antibiotics Noninferior for Lyme Disease

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JAMA. 2022;328(20):2004. doi:10.1001/jama.2022.21305
Health Agencies Update

White House Fixes “Family Glitch” in Health Insurance Subsidies

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JAMA. 2022;328(20):2002. doi:10.1001/jama.2022.18480

New Guidance for Reducing Health Care Organizations’ Carbon Emissions

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JAMA. 2022;328(20):2002. doi:10.1001/jama.2022.18481

GAO Calls for Nationwide Analysis of “Forever Chemicals”

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JAMA. 2022;328(20):2002. doi:10.1001/jama.2022.18482
Poetry and Medicine

Omicron, 621 Days Out

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JAMA. 2022;328(20):2073. doi:10.1001/jama.2022.20561
JAMA Revisited

Development of Bacterial Resistance to Antibiotics

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JAMA. 2022;328(20):2074. doi:10.1001/jama.2021.17225
JAMA Patient Page

What Is Multiple Sclerosis?

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JAMA. 2022;328(20):2078. doi:10.1001/jama.2022.14236

This JAMA Patient Page describes the types of multiple sclerosis and its symptoms, diagnosis, treatment options, and recommended lifestyle modifications.

Comment & Response

Use of Albumin Solution in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

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JAMA. 2022;328(20):2067. doi:10.1001/jama.2022.17488

Use of Albumin Solution in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass—Reply

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JAMA. 2022;328(20):2067-2068. doi:10.1001/jama.2022.17491

US Tracking System for Nonfatal Drug Overdoses

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JAMA. 2022;328(20):2068. doi:10.1001/jama.2022.17494

US Tracking System for Nonfatal Drug Overdoses—Reply

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JAMA. 2022;328(20):2068-2069. doi:10.1001/jama.2022.17497

Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation

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JAMA. 2022;328(20):2069-2070. doi:10.1001/jama.2022.17502

Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation

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JAMA. 2022;328(20):2070. doi:10.1001/jama.2022.17505

Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation

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JAMA. 2022;328(20):2070-2071. doi:10.1001/jama.2022.17499

Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation—Reply

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JAMA. 2022;328(20):2071-2072. doi:10.1001/jama.2022.17508
JAMA Masthead

JAMA

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JAMA. 2022;328(20):1993-1994. doi:10.1001/jama.2021.17222
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