November 22/29, 2022, Vol 328, No. 20, Pages 1993-2078

In This Issue of JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2022;328(20):e2117224. doi:10.1001/jama.2021.17224

Audio: Regular Use of Morphine for Chronic Breathlessness in COPD, Treatment Time and In-Hospital Mortality With STEMI, Change in Travel Time to US Abortion Facilities After Dobbs Decision, and more

Original Investigation

Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial

Magnus Ekström, MD, PhD; Diana Ferreira, MD, PhD; Sungwon Chang, PhD; et al.

Abstract Full Text

JAMA. 2022;328(20):2022-2032. doi:10.1001/jama.2022.20206

This randomized clinical trial compares the effect of different doses (8 mg/d or 16 mg/d) of extended-release morphine vs placebo on chronic breathlessness in people with chronic obstructive pulmonary disease (COPD).

Editorial
Dyspnea—When a Sensation Becomes a Symptom
Richard M. Schwartzstein, MD

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021

James G. Jollis, MD; Christopher B. Granger, MD; Jessica K. Zègre-Hemsey, RN, PhD; et al.

Abstract Full Text

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JAMA. 2022;328(20):2033-2040. doi:10.1001/jama.2022.20149

This cross-sectional study compares in-hospital mortality among patients with ST-segment elevation myocardial infarction receiving treatment within the US national guidelines–recommended target times vs later.

JAMA Medical News Audio: Highlights From the American Heart Association’s Scientific Sessions 2022

Editorial
Time to Treatment in ST-Segment Elevation Myocardial Infarction: Identifying Dangerous Delays or Diminishing Returns?
Andrew S. Oseran, MD, MBA; Robert W. Yeh, MD, MSc

Estimated Travel Time and Spatial Access to Abortion Facilities in the US Before and After the Dobbs v Jackson Women’s Health Decision

Benjamin Rader, MPH; Ushma D. Upadhyay, PhD, MPH; Neil K. R. Sehgal, BA; et al.

Abstract Full Text

JAMA. 2022;328(20):2041-2047. doi:10.1001/jama.2022.20424

This cross-sectional spatial analysis examines travel time from each census tract in the contiguous US to the nearest abortion facility before and after the Dobbs v Jackson Women’s Health Organization US Supreme Court decision.

Editorial
The A Word—Our Collective Scarlet Letter
Melissa A. Simon, MD, MPH

Association of Texas’ 2021 Ban on Abortion in Early Pregnancy With the Number of Facility-Based Abortions in Texas and Surrounding States

Kari White, PhD, MPH; Gracia Sierra, PhD, MS; Klaira Lerma, MPH; et al.

Abstract Full Text

JAMA. 2022;328(20):2048-2055. doi:10.1001/jama.2022.20423

This study assesses changes in the number of abortions and changes in the percentage of out-of-state abortions among Texas residents performed 12 or more weeks of gestation in the first six 6 months following implementation of a Texas senate bill prohibiting abortions after detection of embryonic cardiac activity.

Editorial
The A Word—Our Collective Scarlet Letter
Melissa A. Simon, MD, MPH

Research Letter

Reported Awareness and Adoption of 2021 Estimated Glomerular Filtration Rate Equations Among US Clinical Laboratories, March 2022

Jonathan R. Genzen, MD, PhD; Rhona J. Souers, MS; Lauren N. Pearson, DO, MPH; et al.

Abstract Full Text

JAMA. 2022;328(20):2060-2062. doi:10.1001/jama.2022.15404

This study includes clinical laboratories that participated in the first general chemistry proficiency testing survey in 2022 to assess awareness and adoption of new equations from the Chronic Kidney Disease Epidemiology Collaboration for estimated glomerular filtration rate (eGFR) that eliminated race-adjustment factors, including one based on creatinine and one based on creatinine and cystatin C.

Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial

Stuart H. Cohen, MD; Thomas J. Louie, MD; Matthew Sims, MD, PhD; et al.

Abstract Full Text

JAMA. 2022;328(20):2062-2064. doi:10.1001/jama.2022.16476

This study examines adverse events and durability of response of SER-109, an investigational microbiome therapeutic comprised of purified Firmicutes spores, compared with placebo for Clostridioides difficile infection.

Human Monkeypox Virus Infection in the Immediate Period After Receiving Modified Vaccinia Ankara Vaccine

Aniruddha Hazra, MD; Laura Rusie, ScM; Trevor Hedberg, MPH, PA-C; et al.

Abstract Full Text

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JAMA. 2022;328(20):2064-2067. doi:10.1001/jama.2022.18320

This study uses electronic medical record data to describe monkeypox infections after a single dose of Modified Vaccinia Ankara-Bavarian Nordic vaccine, a live, nonreplicating vaccine indicated for prevention of smallpox and monkeypox infection in adults.

Viewpoint

Closing the Loophole on Hemp-Derived Cannabis Products: A Public Health Priority

Alyssa F. Harlow, PhD, MPH; Adam M. Leventhal, PhD; Jessica L. Barrington-Trimis, PhD

Abstract Full Text

JAMA. 2022;328(20):2007-2008. doi:10.1001/jama.2022.20620

This Viewpoint discusses a federal policy loophole that allows psychotropic cannabis products to be commercially marketed and sold across the US, even in states where recreational cannabis is not legal.

The Tobacco Industry and Harm Reduction

Howard K. Koh, MD, MPH; Michael C. Fiore, MD, MPH, MBA

Abstract Full Text

JAMA. 2022;328(20):2009-2010. doi:10.1001/jama.2022.20679

This Viewpoint discusses the ways in which the tobacco industry can advance their stated goals of harm reduction and a smoke-free future.

Implications of Dobbs for the (Re)Criminalization of Intimacy Among LGBTQ Individuals

Joanne D. Rosen, JD, MA; Chris Beyrer, MD, MPH

Abstract Full Text

JAMA. 2022;328(20):2011-2012. doi:10.1001/jama.2022.20609

This Viewpoint outlines how the revival of now defunct state-level antisodomy laws would harm the health care of LGBTQ individuals should the US Supreme Court reverse itself and urges medical professionals and their societies to advocate for the immediate abolition of antisodomy laws.

A Piece of My Mind

Role Reversal

Julia Brekke-Riedl, PhD

Abstract Full Text

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JAMA. 2022;328(20):2013. doi:10.1001/jama.2022.20556

In this narrative essay, a medical student discusses how observing a patient interacting with her adult daughter was a reminder of the ways in which the roles will eventually be reversed in her relationship with her own young daughter.

Editorial

Dyspnea—When a Sensation Becomes a Symptom

Richard M. Schwartzstein, MD

Abstract Full Text

JAMA. 2022;328(20):2014-2015. doi:10.1001/jama.2022.19248

Time to Treatment in ST-Segment Elevation Myocardial Infarction: Identifying Dangerous Delays or Diminishing Returns?

Andrew S. Oseran, MD, MBA; Robert W. Yeh, MD, MSc

Abstract Full Text

JAMA. 2022;328(20):2016-2017. doi:10.1001/jama.2022.19441

The International Code of Medical Ethics of the World Medical Association

Ramin Walter Parsa-Parsi, MD, MPH

Abstract Full Text

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JAMA. 2022;328(20):2018-2021. doi:10.1001/jama.2022.19697

JAMA Clinical Guidelines Synopsis

Diagnosis and Treatment of Infertility in Men

Joshua A. Halpern, ME, MS; Andrew M. Davis, MD, MPH; Robert E. Brannigan, MD

Abstract Full Text

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JAMA. 2022;328(20):2056-2057. doi:10.1001/jama.2022.19294

This article summarizes guidelines on identifying and addressing infertility in men from the American Urological Association and American Society for Reproductive Medicine.

JAMA Clinical Challenge

Intermittent Chest Pain in a 46-Year-Old Patient

Carlos Plappert, MD; Mohammad Sherif, MD; Christian Oeing, MD

Abstract Full Text

has active quiz

JAMA. 2022;328(20):2058-2059. doi:10.1001/jama.2022.19443

A patient in his 40s presented to the emergency department with chest pain and diaphoresis, which had also occurred 2 days earlier. He had a 20 pack-year history of smoking but no family history of cardiovascular disease. The patient’s electrocardiogram showed biphasic T waves in leads V₂ and V₃. What would you do next?

Medical News & Perspectives

After the First Pig-to-Human Heart Transplant, Scientists Look to the Future of Cardiac Xenotransplantation

Jyoti Madhusoodanan

Abstract Full Text

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JAMA. 2022;328(20):1999-2001. doi:10.1001/jama.2022.15434

This Medical News article discusses how cardiac xenotransplantation with genetically modified pig hearts might help relieve the shortage of human donor hearts.

JAMA Medical News Audio: Highlights From the American Heart Association’s Scientific Sessions 2022
Audio: November 2022 Medical News Summary

News From the Centers for Disease Control and Prevention

CDC Report: Urgent Need to Address Teens’ Adverse Experiences During Pandemic

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2022;328(20):2005. doi:10.1001/jama.2022.18488

Targeted Flu Vaccination Campaigns Needed for Certain Racial and Ethnic Groups

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2022;328(20):2005. doi:10.1001/jama.2022.18487

Clinical Trials Update

Financial Vouchers Led to Higher Smoking Abstinence During Pregnancy

Anita Slomski

Abstract Full Text

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JAMA. 2022;328(20):2003. doi:10.1001/jama.2022.18484

Intranasal COVID-19 Vaccine Disappointing in First-in-Human Trial

Anita Slomski

Abstract Full Text

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JAMA. 2022;328(20):2003. doi:10.1001/jama.2022.18485

Colonoscopy Did Not Reduce Cancer Deaths in Trial

Anita Slomski

Abstract Full Text

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JAMA. 2022;328(20):2003-2004. doi:10.1001/jama.2022.18486

Shorter Duration of Antibiotics Noninferior for Lyme Disease

Anita Slomski

Abstract Full Text

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JAMA. 2022;328(20):2004. doi:10.1001/jama.2022.21305

Health Agencies Update

White House Fixes “Family Glitch” in Health Insurance Subsidies

Melissa Suran, PhD, MSJ

Abstract Full Text

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JAMA. 2022;328(20):2002. doi:10.1001/jama.2022.18480

New Guidance for Reducing Health Care Organizations’ Carbon Emissions

Melissa Suran, PhD, MSJ

Abstract Full Text

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JAMA. 2022;328(20):2002. doi:10.1001/jama.2022.18481

GAO Calls for Nationwide Analysis of “Forever Chemicals”

Melissa Suran, PhD, MSJ

Abstract Full Text

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JAMA. 2022;328(20):2002. doi:10.1001/jama.2022.18482

Poetry and Medicine

Omicron, 621 Days Out

Stacy Nigliazzo, MSN, RN

Abstract Full Text

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JAMA. 2022;328(20):2073. doi:10.1001/jama.2022.20561

JAMA Revisited

Development of Bacterial Resistance to Antibiotics

Abstract Full Text

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JAMA. 2022;328(20):2074. doi:10.1001/jama.2021.17225

JAMA Patient Page

What Is Multiple Sclerosis?

Revital Marcus, MD

Abstract Full Text

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JAMA. 2022;328(20):2078. doi:10.1001/jama.2022.14236

This JAMA Patient Page describes the types of multiple sclerosis and its symptoms, diagnosis, treatment options, and recommended lifestyle modifications.