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September 14, 2021, Vol 326, No. 10, Pages 889-984

In This Issue of JAMA

Audio Highlights

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JAMA. 2021;326(10):e2018121. doi:10.1001/jama.2020.18121
Original Investigation

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial

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JAMA. 2021;326(10):916-925. doi:10.1001/jama.2021.12836

This clinical trial compares overall and progression-free survival of patients with advanced or metastatic esophageal squamous cell carcinoma randomized to camrelizumab plus chemotherapy or to placebo plus chemotherapy.

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial

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JAMA. 2021;326(10):926-939. doi:10.1001/jama.2021.10207

This randomized clinical trial assesses whether sustained urate-elevating treatment with the urate precursor inosine, compared with placebo, slows rate of clinical disease progression among patients with early Parkinson disease.

Caring for the Critically Ill Patient

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial

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JAMA. 2021;326(10):940-948. doi:10.1001/jama.2021.13011

This clinical trial compares the effectiveness of a low-normal Pao2 target vs a high-normal Pao2 target to reduce organ dysfunction in critically ill patients with systemic inflammatory response syndrome.

Research Letter

Trends in Mortality From COVID-19 and Other Leading Causes of Death Among Latino vs White Individuals in Los Angeles County, 2011-2020

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JAMA. 2021;326(10):973-974. doi:10.1001/jama.2021.11945

This study compares age-adjusted mortality rates before and during the COVID-19 pandemic (2011-2020) among Latino and White individuals living in Los Angeles County.

US Preventive Services Task Force

Recommendation Statement

Screening for Chlamydia and Gonorrhea: US Preventive Services Task Force Recommendation Statement

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JAMA. 2021;326(10):949-956. doi:10.1001/jama.2021.14081

This 2021 Recommendation Statement from the US Preventive Services Task Force recommends that all sexually active women 24 years or younger and women 25 years or older at increased risk for infection be screened for chlamydia (B recommendation) and gonorrhea (B recommendation) and concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for chlamydia and gonorrhea in men (I statement).

Evidence Report

Screening for Chlamydial and Gonococcal Infections: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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JAMA. 2021;326(10):957-966. doi:10.1001/jama.2021.10577

This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for chlamydial and gonococcal infections summarizes published evidence on the benefits and harms of screening for chlamydial and gonococcal infection in adults and adolescents, including those who are pregnant.

Viewpoint

Making Vaccines Available to Other Countries Before Offering Domestic Booster Vaccinations

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JAMA. 2021;326(10):903-904. doi:10.1001/jama.2021.13226

This Viewpoint highlights countries with higher concentrations of COVID-19–vaccinated residents and and excess vaccine supply vs those without, and it emphasizes the clinical and ethical reasons for prioritizing distribution of excess vaccine to underserved countries instead of keeping it for booster administration.

Setting the Stage for the Next 10 Years of Health Care Payment Innovation

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JAMA. 2021;326(10):905-906. doi:10.1001/jama.2021.13153

This Viewpoint describes 4 health policy strategies that could help lead to improvements in cost and quality in the US health care system.

Private Equity and Health Care Delivery: Value-Based Payment as a Guardrail?

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JAMA. 2021;326(10):907-908. doi:10.1001/jama.2021.13197

This Viewpoint considers how payment models may dictate the nature of private equity investment in health care delivery and how these investments may affect health care access, quality, equity, and affordability.

A Piece of My Mind

Preventing a Pandemic's Toll—We've Been Here Before

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JAMA. 2021;326(10):909-910. doi:10.1001/jama.2021.14402

In this narrative medicine essay, an infectious diseases physician recalls the reluctance of some patients with AIDS who feared taking antiretroviral medications, offering the same arguments being raised for refusing COVID vaccinations, and suggests that story telling may be a compelling way to convince people to be vaccinated.

Editorial

Titrating Oxygen Therapy in Critically Ill Patients

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JAMA. 2021;326(10):911-913. doi:10.1001/jama.2021.9843

Screening for Chlamydia and Gonorrhea

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JAMA. 2021;326(10):913-915. doi:10.1001/jama.2021.14773
JAMA Guide to Statistics and Methods

Estimands, Estimators, and Estimates

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JAMA. 2021;326(10):967-968. doi:10.1001/jama.2021.2886

This JAMA Guide to Statistics and Methods takes a look at estimands, estimators, and estimates in the context of randomized clinical trials and suggests several qualities that make for good estimands, including their scope, ability to summarize treatment effects, external validity, and ability to provide good estimates.

JAMA Insights

Pulmonary Rehabilitation in 2021

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JAMA. 2021;326(10):969-970. doi:10.1001/jama.2021.6560

This JAMA Insights Clinical Update provides an overview of pulmonary rehabilitation, including patient candidacy, the process and components, and expected outcomes.

Medical News & Perspectives

Influenza’s Unprecedented Low Profile During COVID-19 Pandemic Leaves Experts Wondering What This Flu Season Has in Store

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JAMA. 2021;326(10):899-900. doi:10.1001/jama.2021.14131

This Medical News feature examines potential scenarios about how severe the upcoming flu season might be, given the dearth of influenza worldwide since the COVID-19 pandemic began.

News From the Centers for Disease Control and Prevention

Adolescent Myocarditis After COVID-19 Vaccination Is Rare

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JAMA. 2021;326(10):902. doi:10.1001/jama.2021.14237

Severe Tuberculosis Surged After Shelter-in-Place Lifted

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JAMA. 2021;326(10):902. doi:10.1001/jama.2021.14683
Biotech Innovations

SARS-CoV-2 Variant Antibodies Wane 6 Months After Vaccination

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JAMA. 2021;326(10):901. doi:10.1001/jama.2021.15115

Potential New Immune-Checkpoint Inhibitor Partner for Lung Cancer

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JAMA. 2021;326(10):901. doi:10.1001/jama.2021.14765

Point-of-Care SARS-CoV-2 Variant Diagnostic in Development

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JAMA. 2021;326(10):901. doi:10.1001/jama.2021.15116
Poetry and Medicine

Taxonomy of the Oaks

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JAMA. 2021;326(10):980. doi:10.1001/jama.2021.10293
JAMA Revisited

The Fad for Pseudoscience: Pertinent Queries and Musings

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JAMA. 2021;326(10):981. doi:10.1001/jama.2020.18122
JAMA Patient Page

Screening for Chlamydia and Gonorrhea

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JAMA. 2021;326(10):984. doi:10.1001/jama.2021.14770

This JAMA Patient Page summarizes the US Preventive Services Task Force’s recent recommendations on screening for chlamydia and gonorrhea in adolescents and adults.

Comment & Response

Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease

Abstract Full Text
JAMA. 2021;326(10):974-975. doi:10.1001/jama.2021.11097

Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease

Abstract Full Text
JAMA. 2021;326(10):975. doi:10.1001/jama.2021.11100

Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease—Reply

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JAMA. 2021;326(10):975-976. doi:10.1001/jama.2021.11103

A Review of the Diagnosis and Management of Headache

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JAMA. 2021;326(10):976. doi:10.1001/jama.2021.11373

A Review of the Diagnosis and Management of Headache

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JAMA. 2021;326(10):977. doi:10.1001/jama.2021.11376

A Review of the Diagnosis and Management of Headache

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JAMA. 2021;326(10):977. doi:10.1001/jama.2021.11370

A Review of the Diagnosis and Management of Headache—Reply

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JAMA. 2021;326(10):977-978. doi:10.1001/jama.2021.11379
Correction

Percentage Incorrect in 2 Places

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JAMA. 2021;326(10):978. doi:10.1001/jama.2021.13853

Disclosures Added to Medical News Story

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JAMA. 2021;326(10):978. doi:10.1001/jama.2021.14538
JAMA Masthead

JAMA

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JAMA. 2021;326(10):889-890. doi:10.1001/jama.2020.18119
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