This randomized trial compares the effects of oral methotrexate, 25 mg weekly vs oral mycophenolate mofetil, 3 g daily, on measures of inflammation in patients with noninfectious uveitis.
This randomized clinical trial compares a multicomponent home-based physical therapy intervention with an active control on ability to walk in daily life among adults aged 60 years and older who had experienced a nonpathologic, minimal trauma hip fracture.
This cohort study characterizes the association of for-profit vs nonprofit dialysis facility ownership with placement on the deceased donor kidney transplantation waiting list or receipt of a living donor or a deceased donor kidney transplant.
To estimate changes in oral human papillomavirus (HPV) prevalence attributable to vaccination vs herd immunity, this national survey study uses National Health and Nutrition Examination Survey data to compare oral HPV prevalence for 4 types targeted by HPV vaccine and 33 nonvaccine types in unvaccinated US adults aged 18 to 59 years from 2009 to 2016.
This Viewpoint reviews the molecular basis of sickle cell disease (SCD), the history of treatments for the disease, and recent progress toward curative therapies including HSCT and gene therapy and editing, emphasizing that research and innovation needs to take into account patient priorities and perspectives given the history of research mistreatment of minority groups most affected by SCD.
This Viewpoint discusses existing mechanisms of Medicare reimbursement for chimeric antigen receptor (CAR) T-cell therapy, which at US $375 000 to $475 000 per treatment is prohibitively expensive, and proposes ways to mitigate the challenges of covering the therapy appropriately and equitably for those who need it while realistically managing cost constraints.
This Viewpoint discusses advantages and theoretical harms of direct-to-consumer drug telemedicine, whereby patients obtain prescription drugs through online visits, and calls for monitoring of for-profit DTC direct-to-consumer telemedicine ventures (eg, Curology, Hims, Nurx, and The Pill Club) to ensure that quality and safety are not being sacrificed for convenience of care.
This Viewpoint reviews the FDA’s 510(k) premarket review pathway through which many medical devices are brought into the US market based on “substantial equivalence” to a currently available device and the FDA’s 2019 guidance for an alternative “Safety and Performance Based Pathway,” and proposes additional strategies and policies to reduce harms from 510(k) approval mechanism and improve the safety and effectiveness of medical devices.
In this narrative medicine essay, a dermatologist recalls his moments with his grandmother a fierce educator and administrator in the New York City Schools who taught him about life and death with advice and by example and whom he helped guide through her transition at 96 years—proud to be her medical advocate, sad to let her go.
This JAMA Insights Clinical Update reviews what is known and not known about the efficacy and safety of cannabis and cannabinoids for managing medical conditions, distinguishing between FDA-approved indications, nonapproved indications supported by high-quality emerging evidence, and current claims and uses for which there is inadequate evidence.
This Medical News article discusses a clinical trial to delay the onset of type 1 diabetes in high-risk relatives of people with the disease.
This Medical News article discusses a controversy around limbic-predominant age-related TDP-43 encephalopathy, or LATE, a recently recognized dementia that mimics Alzheimer disease.
This Appendix presents data from the 2018-2019 Liaison Committee on Medical Education (LCME) annual questionnaire detailing information on the number of students, student demographics, curriculum content, and enrollment at US medical schools.
This Appendix presents 2018 National GME Census data detailing the numbers and types of ACGME-accredited training programs and the residents and fellows in them.
This JAMA Patient Page describes the symptoms, diagnosis, treatment, and prevention of mumps.
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