This multicenter, double-blind, randomized trial conducted in nasopharyngeal cancer (NPC)–endemic regions assesses whether toripalimab in combination with gemcitabine-cisplatin as first-line treatment for recurrent or metastatic NPC, compared with gemcitabine-cisplatin alone, will significantly improve progression-free survival and overall survival among chemotherapy-naive patients with recurrent or metastatic NPC.
This randomized clinical trial assessed rates of adherence to undergo cervical cancer screening by comparing response rates to various outreach strategies among individuals who were due or overdue for screening and who had unknown screening history.
This randomized clinical trial compares the efficacy of sighs in addition to usual care vs usual care alone in improving clinical outcomes among trauma patients receiving mechanical ventilation and are at risk for developing acute respiratory distress syndrome.
This clinical trial assesses whether physician-guided self-management of antihypertensive medication results in persistently lower blood pressure after a hypertensive pregnancy compared with usual care.
This study examines the rate of employment in US health care in the postpandemic period, through the end of 2022.
This cross-sectional, exploratory study uses ClinicalTrials.gov data from trials initiated on or after January 18, 2017, to characterize the use of a new free-text “gender eligibility description” data field; reports the frequency of gender identity terms used; and assesses the correct or incorrect use of the field.
Authors of this Viewpoint present actionable steps for regulatory, industry, and health care organization practices to accelerate reduction of single-use plastics and help protect planetary and human health.
This Viewpoint emphasizes the importance of policy statements using “person-first” language to mitigate discrimination against people with disabilities and to boost modern views in the medical and research communities.
This Viewpoint examines the importance of the Supreme Court decision in 303 Creative and its possible effects on legislation safeguarding nondiscriminatory health care.
In this narrative medicine essay, a family medicine physician whose daughter was born with a 50% chance of having the Huntingtin gene embraces the joy of the present over the fear of the future.
This Review summarizes current evidence regarding the pathophysiology, diagnosis, and treatment of obesity.
On day 7 after hospital admission, a patient with end-stage kidney disease prescribed sevelamer, hydrocodone-acetaminophen, hydromorphone, and chewable lanthanum tablets developed intermittent apneic episodes, bilateral rhonchi, and responsiveness to verbal commands only with deep painful stimulus; a chest radiograph showed 4 radio-opaque coin-shaped opacities in the stomach. What is the diagnosis and what would you do next?
In this Medical News article, Johns Hopkins University computer scientist Suchi Saria, PhD, MSc, discusses the use of AI tools in early sepsis detection and other clinical applications.
This Medical News article discusses new research presented at the 2023 United European Gastroenterology Week held in Copenhagen, Denmark.
This Arts and Medicine feature reviews The Autumn Ghost, an historical retelling of the 1952 polio epidemic in Copenhagen, Denmark, which catalyzed developments in anesthesia and respiratory support procedures that are still in use today.
This JAMA Patient Page discusses screening for cervical cancer, including who should be screened, recommendations for handling positive results, and the prevention of cervical cancer.