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January 25, 2022, Vol 327, No. 4, Pages 305-401

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2022;327(4):e2116822. doi:10.1001/jama.2021.16822
Original Investigation

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

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JAMA. 2022;327(4):331-340. doi:10.1001/jama.2021.24110

This descriptive study compares the effect of mRNA-based COVID-19 vaccination with BNT162b2 (Pfizer-BioNTech) vs mRNA-1273 (Moderna) on the reported cases of myocarditis in the US after each vaccination dose.

Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel

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JAMA. 2022;327(4):341-349. doi:10.1001/jama.2021.23641

This cohort study estimates the association of a BNT162b2 (Pfizer-BioNTech) vaccine booster dose with SARS-CoV-2 infections among health care workers in Israel previously vaccinated with a 2-dose series of BNT162b2.

Population-Based Penetrance of Deleterious Clinical Variants

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JAMA. 2022;327(4):350-359. doi:10.1001/jama.2021.23686

This study uses data from 2 large electronic health record–linked biobanks to estimate variant penetrance.

Research Letter

Hip Fracture Surgery Volumes Among Individuals 65 Years and Older During the COVID-19 Pandemic

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JAMA. 2022;327(4):387-388. doi:10.1001/jama.2021.23761

This study assesses hip fracture surgery volumes among older individuals in California during the pandemic compared with prepandemic rates.

Aspirin Use for Preeclampsia Prevention Among Women With Prepregnancy Diabetes, Obesity, and Hypertension

Abstract Full Text
JAMA. 2022;327(4):388-390. doi:10.1001/jama.2021.22749

This study estimates aspirin use for preeclampsia prevention in pregnant women with prepregnancy diabetes, obesity, chronic hypertension, and combinations of these factors in 2018-2020.

US Preventive Services Task Force

Recommendation Statement

Screening for Atrial Fibrillation: US Preventive Services Task Force Recommendation Statement

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JAMA. 2022;327(4):360-367. doi:10.1001/jama.2021.23732

This 2022 Recommendation Statement from the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for AF (I statement).

Evidence Report

Screening for Atrial Fibrillation: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

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JAMA. 2022;327(4):368-383. doi:10.1001/jama.2021.21811

This systematic review to support the 2022 US Preventive Services Task Force Recommendation Statement on screening for atrial fibrillation (AF) summarizes published evidence on the benefits and harms of screening and anticoagulant therapy among asymptomatic persons without known AF or prior stroke.

Viewpoint

Diagnostic Excellence

The Rational Diagnostician and Achieving Diagnostic Excellence

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JAMA. 2022;327(4):317-318. doi:10.1001/jama.2021.24988

This Viewpoint outlines approaches to successfully make clinical diagnoses, including coaching medical students in critical thinking and decision-making, promoting interdisciplinary teamwork, and mitigating judgment and decision-making biases.

Winter of Omicron—The Evolving COVID-19 Pandemic

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JAMA. 2022;327(4):319-320. doi:10.1001/jama.2021.24315

This Viewpoint discusses the Omicron variant of SARS-CoV-2, including its likely origin, the importance of vaccination, the other tools available to combat a surge in COVID-19 cases, and the possibility of a “twindemic” with influenza.

Shifting to Serious Illness Communication

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JAMA. 2022;327(4):321-322. doi:10.1001/jama.2021.23695

This Viewpoint focuses on an emerging intervention, serious illness communication, and describes its components, presents evidence supporting the approach, and discusses areas for further research.

The Dysfunctional Health Benefits Market and Implications for US Employers and Employees

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JAMA. 2022;327(4):323-324. doi:10.1001/jama.2021.23258

This Viewpoint discusses addressing the problems in the health benefits market, which contribute to wage stagnation and rising economic inequality.

A Piece of My Mind

Poppy’s Final Lesson

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JAMA. 2022;327(4):325-326. doi:10.1001/jama.2021.24576

In this narrative medicine essay, a critical care physician recounts his final visit with his dying grandfather and how the experience helped inform his view of medicine as he began a fellowship in palliative medicine.

Editorial

Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection

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JAMA. 2022;327(4):327-328. doi:10.1001/jama.2021.23726

Screening for Atrial Fibrillation—More Data Still Needed

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JAMA. 2022;327(4):329-330. doi:10.1001/jama.2021.23727
From The Medical Letter on Drugs and Therapeutics

Tixagevimab and Cilgavimab (Evusheld) for Pre-Exposure Prophylaxis of COVID-19

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JAMA. 2022;327(4):384-385. doi:10.1001/jama.2021.24931

This Medical Letter review summarizes the use of tixagevimab and cilgavimab (Evusheld), investigational long-acting monoclonal antibodies to be administered concomitantly by intramuscular injection for preexposure prophylaxis of COVID-19 in persons aged 12 years or older.

Medical News & Perspectives

Highlights From the American Heart Association’s Scientific Sessions—ApoB as a Risk Marker, an Oral PCSK9 Inhibitor, and Aspirin and Dementia

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JAMA. 2022;327(4):310-312. doi:10.1001/jama.2021.21397

Timely topics discussed at the American Heart Association’s Scientific Sessions in November 2021 included using apolipoprotein B to predict the risk of future myocardial infarction.

News From the Centers for Disease Control and Prevention

Fall Influenza A(H3N2) Outbreak at a Midwestern University

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JAMA. 2022;327(4):315. doi:10.1001/jama.2021.23854

CDC Establishes Global Networks to Combat Antimicrobial Resistance

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JAMA. 2022;327(4):315. doi:10.1001/jama.2021.24379
Clinical Trials Update

Financial Incentives Help People Quit Smoking During Pregnancy

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JAMA. 2022;327(4):314. doi:10.1001/jama.2021.23106

Apixaban vs Rivaroxaban for Preventing Recurrent VTE

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JAMA. 2022;327(4):314. doi:10.1001/jama.2021.25108

Teriflunomide Reduced Lesions in Pediatric Multiple Sclerosis

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JAMA. 2022;327(4):314. doi:10.1001/jama.2021.25109

Surgery Improves Relapsed Ovarian Cancer Survival

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JAMA. 2022;327(4):314. doi:10.1001/jama.2021.25110
Health Agencies Update

Increased Use of Medicare Telehealth During the Pandemic

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JAMA. 2022;327(4):313. doi:10.1001/jama.2021.23332

Coverage of COVID-19 Vaccine Counseling for Children and Youths

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JAMA. 2022;327(4):313. doi:10.1001/jama.2021.25080

Oncostatin M Cytokine Associated With Chronic Itch

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JAMA. 2022;327(4):313. doi:10.1001/jama.2021.25081
Poetry and Medicine

How to Go Forward After Your Second Child Dies

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JAMA. 2022;327(4):396. doi:10.1001/jama.2021.21627
JAMA Revisited

An Educational Model

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JAMA. 2022;327(4):397. doi:10.1001/jama.2021.16823
JAMA Patient Page

Screening for Atrial Fibrillation

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JAMA. 2022;327(4):401. doi:10.1001/jama.2021.24513

This JAMA Patient Page summarizes the recent recommendations from the US Preventive Services Task Force on screening for atrial fibrillation.

Comment & Response

Combined Varenicline With Nicotine Patch and Extended Duration of Therapy for Smoking Cessation

Abstract Full Text
JAMA. 2022;327(4):390-391. doi:10.1001/jama.2021.22661

Combined Varenicline With Nicotine Patch and Extended Duration of Therapy for Smoking Cessation—Reply

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JAMA. 2022;327(4):391-392. doi:10.1001/jama.2021.22664

Clinical Challenge About Retinal Artery Thrombosis and Aortic Valve Vegetations

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JAMA. 2022;327(4):392. doi:10.1001/jama.2021.22905

Clinical Challenge About Retinal Artery Thrombosis and Aortic Valve Vegetations—Reply

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JAMA. 2022;327(4):392. doi:10.1001/jama.2021.22908

Association of Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome

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JAMA. 2022;327(4):392-393. doi:10.1001/jama.2021.23003

Presumptive Guillain-Barré Syndrome Associated With Receipt of the Ad26.COV2.2.S COVID-19 Vaccine—Reply

Abstract Full Text
JAMA. 2022;327(4):393-394. doi:10.1001/jama.2021.23006
Correction

Data Plotted Incorrectly in Figure 2

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JAMA. 2022;327(4):394. doi:10.1001/jama.2021.24545
JAMA Masthead

JAMA

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JAMA. 2022;327(4):305-306. doi:10.1001/jama.2021.16820
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