This clinical trial compares overall and progression-free survival of patients with advanced or metastatic esophageal squamous cell carcinoma randomized to camrelizumab plus chemotherapy or to placebo plus chemotherapy.
This randomized clinical trial assesses whether sustained urate-elevating treatment with the urate precursor inosine, compared with placebo, slows rate of clinical disease progression among patients with early Parkinson disease.
This clinical trial compares the effectiveness of a low-normal Pao2 target vs a high-normal Pao2 target to reduce organ dysfunction in critically ill patients with systemic inflammatory response syndrome.
This study compares age-adjusted mortality rates before and during the COVID-19 pandemic (2011-2020) among Latino and White individuals living in Los Angeles County.
This 2021 Recommendation Statement from the US Preventive Services Task Force recommends that all sexually active women 24 years or younger and women 25 years or older at increased risk for infection be screened for chlamydia (B recommendation) and gonorrhea (B recommendation) and concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for chlamydia and gonorrhea in men (I statement).
This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for chlamydial and gonococcal infections summarizes published evidence on the benefits and harms of screening for chlamydial and gonococcal infection in adults and adolescents, including those who are pregnant.
This Viewpoint highlights countries with higher concentrations of COVID-19–vaccinated residents and and excess vaccine supply vs those without, and it emphasizes the clinical and ethical reasons for prioritizing distribution of excess vaccine to underserved countries instead of keeping it for booster administration.
This Viewpoint describes 4 health policy strategies that could help lead to improvements in cost and quality in the US health care system.
This Viewpoint considers how payment models may dictate the nature of private equity investment in health care delivery and how these investments may affect health care access, quality, equity, and affordability.
In this narrative medicine essay, an infectious diseases physician recalls the reluctance of some patients with AIDS who feared taking antiretroviral medications, offering the same arguments being raised for refusing COVID vaccinations, and suggests that story telling may be a compelling way to convince people to be vaccinated.
This JAMA Guide to Statistics and Methods takes a look at estimands, estimators, and estimates in the context of randomized clinical trials and suggests several qualities that make for good estimands, including their scope, ability to summarize treatment effects, external validity, and ability to provide good estimates.
This JAMA Insights Clinical Update provides an overview of pulmonary rehabilitation, including patient candidacy, the process and components, and expected outcomes.
This Medical News feature examines potential scenarios about how severe the upcoming flu season might be, given the dearth of influenza worldwide since the COVID-19 pandemic began.
This JAMA Patient Page summarizes the US Preventive Services Task Force’s recent recommendations on screening for chlamydia and gonorrhea in adolescents and adults.
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