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August 9, 2022, Vol 328, No. 6, Pages 497-593

In This Issue of JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2022;328(6):e2117084. doi:10.1001/jama.2021.17084
Original Investigation

Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial

Abstract Full Text
JAMA. 2022;328(6):534-542. doi:10.1001/jama.2022.12000

This randomized clinical trial compares the efficacy of percutaneous transluminal angioplasty and stenting plus medical therapy vs medical therapy alone in reducing the risk of stroke or death among patients with symptomatic severe intracranial atherosclerotic stenosis.

Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial

Abstract Full Text
JAMA. 2022;328(6):543-553. doi:10.1001/jama.2022.12584

This clinical trial examines whether intravenous tirofiban could improve disability severity without increasing symptomatic intracranial hemorrhage or mortality in patients with acute ischemic stroke and proximal large vessel occlusions undergoing endovascular treatment.

Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis

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JAMA. 2022;328(6):554-562. doi:10.1001/jama.2022.11966

This systematic review and individual patient data meta-analysis of randomized clinical trials compares the effects of ticagrelor dual antiplatelet therapy or ticagrelor monotherapy with aspirin on saphenous vein graft failure among patients undergoing coronary artery bypass graft surgery.

Association of Younger vs Older Ages With Changes in Incidence of Stroke and Other Vascular Events, 2002-2018

Abstract Full Text
JAMA. 2022;328(6):563-574. doi:10.1001/jama.2022.12759

This study assesses time trends in incidence of stroke, transient ischemic attack, and other major vascular events at younger vs older ages in a population living in Oxfordshire, England, in 2002-2018.

Research Letter

US Food and Drug Administration Approval of High-risk Cardiovascular Devices for Use in Children and Adolescents, 1977-2021

Abstract Full Text
JAMA. 2022;328(6):580-582. doi:10.1001/jama.2022.10041

This study uses data from US Food and Drug Administration (FDA) databases to quantify approval of high-risk cardiovascular devices for use in pediatric populations and assess the clinical evidence supporting the approvals.

Olfactory Dysfunction in Patients With Mild COVID-19 During Gamma, Delta, and Omicron Waves in Rio de Janeiro, Brazil

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JAMA. 2022;328(6):582-583. doi:10.1001/jama.2022.11006

This study uses data obtained through an updated version of the Brazilian National Health System Questionnaire for COVID-19 to assess olfactory dysfunction in patients with mild COVID-19 in Rio de Janeiro, Brazil.

Viewpoint

Addressing Well-being Throughout the Health Care Workforce: The Next Imperative

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JAMA. 2022;328(6):521-522. doi:10.1001/jama.2022.12437

This Viewpoint discusses how the coronavirus pandemic has highlighted the burnout felt by the entire health care workforce, including nursing assistants, transport personnel, and clerical staff, and how this can be addressed through a blended approach that improves workforce well-being, the health care system, and patients’ health.

Making Electronic Health Records Both SAFER and SMARTER

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JAMA. 2022;328(6):523-524. doi:10.1001/jama.2022.12243

This Viewpoint discusses shortcomings of current electronic health record (EHR) implementation, summarizes how the CMS SAFER Guides can in part address these shortcomings by lessening cognitive load of EHR tasks, and proposes a 7-dimension SMARTER Guide to further lessen cognitive load, increase cognitive support, and advance measurement and improvement of EHR technology.

Diagnostic Excellence

Achieving Diagnostic Excellence for Cancer: Symptom Detection as a Partner to Screening

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JAMA. 2022;328(6):525-526. doi:10.1001/jama.2022.11744

This Viewpoint discusses the need to expand early cancer detection to include both screening and symptom detection to achieve the goal of diagnostic excellence for cancer.

A Piece of My Mind

Reading Camus in Our Time of Plague

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JAMA. 2022;328(6):527-528. doi:10.1001/jama.2022.12798

In this narrative medicine essay, an infectious diseases physician ponders how working through the COVID pandemic has changed her even though the words to explain it elude her and finds solace in the experience described in the Camus novel The Plague.

Editorial

Therapeutic Strategies for Intracranial Atherosclerosis

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JAMA. 2022;328(6):529-531. doi:10.1001/jama.2022.11525

Balancing the Risks and Benefits of Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery

Abstract Full Text
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JAMA. 2022;328(6):532-533. doi:10.1001/jama.2022.12444
JAMA Insights

Women's Health

Contraception in Women With Cardiovascular Disease

Abstract Full Text
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JAMA. 2022;328(6):577-578. doi:10.1001/jama.2022.11541

This JAMA Insights in Women’s Health series summarizes the prevalence of cardiovascular disease among women of childbearing age, the most effective forms of contraception based on the patient’s medical condition and preference, and the risks and adverse effects associated with contraindicated forms of contraception.

JAMA Clinical Guidelines Synopsis

Therapy for Mild to Moderate Asthma

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JAMA. 2022;328(6):575-576. doi:10.1001/jama.2022.12258

This article summarizes a guideline on the prevention and treatment of mild to moderate asthma, produced by the Global Initiative for Asthma (GINA).

Medical News & Perspectives

MASALA Study Probes Why People With South Asian Ancestry Have Increased Cardiovascular Disease Risks

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JAMA. 2022;328(6):511-514. doi:10.1001/jama.2022.11417

This Medical News article is an interview with Alka Kanaya, MD, and Namratha Kandula, MD, MPH, principal investigators on the Mediators of Atherosclerosis in South Asians Living in America (MASALA) prospective cohort study.

Lawsuits, Reimbursement, and Liability Insurance—Facing the Realities of a Post-Roe Era

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JAMA. 2022;328(6):515-517. doi:10.1001/jama.2022.9193

Clinicians face an array of legal uncertainties surrounding abortion care since the US Supreme Court overturned Roe v Wade in June.

News From the Centers for Disease Control and Prevention

More Effective Flu Vaccines Recommended for Older Adults

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JAMA. 2022;328(6):519. doi:10.1001/jama.2022.12520

Reduced HIV Testing and Diagnoses During COVID-19 Pandemic

Abstract Full Text
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JAMA. 2022;328(6):519. doi:10.1001/jama.2022.12790
Biotech Innovations

New “Universal” Flu Vaccine Candidate Enters Clinical Trial

Abstract Full Text
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JAMA. 2022;328(6):518. doi:10.1001/jama.2022.13252

Evolving Omicron Subvariants Are More Resistant to Antibody Therapy

Abstract Full Text
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JAMA. 2022;328(6):518. doi:10.1001/jama.2022.12859

Finding Ways to Improve Patients’ Cancer Immunotherapy Response

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JAMA. 2022;328(6):518. doi:10.1001/jama.2022.13253
The Arts and Medicine

Art and the Fight Against Tuberculosis

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JAMA. 2022;328(6):509-510. doi:10.1001/jama.2021.24029

This Arts and Medicine essay reviews the work of visual artist Paula Siniatkina, who has used her experience as a patient previously quarantined and treated for tuberculosis to create art intended to represent and destigmatize the disease.

Poetry and Medicine

To My Husband With Alzheimer Disease

Abstract Full Text
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JAMA. 2022;328(6):587. doi:10.1001/jama.2022.9184
JAMA Revisited

Miscellany

Abstract Full Text
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JAMA. 2022;328(6):588. doi:10.1001/jama.2021.17085
JAMA Patient Page

What Is Carpal Tunnel Syndrome?

Abstract Full Text
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JAMA. 2022;328(6):593. doi:10.1001/jama.2022.10522

This JAMA Patient Page describes carpal tunnel syndrome and its symptoms, risk factors, diagnosis, and treatment options.

Comment & Response

Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care for Adults With Peripheral Artery Disease

Abstract Full Text
JAMA. 2022;328(6):584. doi:10.1001/jama.2022.9750

Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care for Adults With Peripheral Artery Disease—Reply

Abstract Full Text
JAMA. 2022;328(6):584-585. doi:10.1001/jama.2022.9753

Prevalence of Cigarette Smoking Among US Adults With Major Depression or Substance Use Disorders

Abstract Full Text
JAMA. 2022;328(6):585. doi:10.1001/jama.2022.10852

Prevalence of Cigarette Smoking Among US Adults With Major Depression or Substance Use Disorders—Reply

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JAMA. 2022;328(6):585-586. doi:10.1001/jama.2022.10855
Correction

Incorrect Reference

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JAMA. 2022;328(6):586. doi:10.1001/jama.2022.12137
JAMA Masthead

JAMA

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JAMA. 2022;328(6):497-498. doi:10.1001/jama.2021.17082
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