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April 7, 1962

The Long-Term Response of Diabetes Mellitus to Salicylate Therapy: Report of a Case

Author Affiliations


JAMA. 1962;180(1):65-66. doi:10.1001/jama.1962.03050140067017c

SALICYLATES, like the sulfonylurea drugs, lower the blood sugar levels of diabetics whether given by the intravenous or oral route. Salicylates, unlike the sulfonylureas, do not appear to affect the blood sugars of normals.

The potential usefulness of these drugs in the treatment of diabetes mellitus has been indicated by the results of several short-term clinical trials. The effectiveness of salicylates in the treatment of diabetes for longer periods of time is suggested by our observations in 8 patients whose blood sugars were maintained at satisfactory levels for from 3 to 28 months. We wish to report in detail the case study of one patient who, following a secondary failure of tolbutamide, has been effectively controlled with oral acetylsalicylic acid for 28 months.

Report of a Case

A 69-year-old housewife was first admitted to the Jefferson Medical College Hospital in 1954, when a diagnosis of pernicious anemia was made, and

Gilgore, S. G., and Rupp, J. J.:  Response of Blood Glucose to Intravenous Salicylate ,  Metabolism 10:419, 1961.
Reid, J., and McDougal, A. I.:  Aspirin and Diabetes ,  Brit Med J 2:1071, 1957.Crossref
Hecht, A., and Goldner, M.:  Reappraisal of Hypoglycemic Action of Acetylsalicylate ,  Metabolism , 8:4, 1959.
Gilgore, S. G.:  Influence of Salicylate on Hyperglycemia ,  Diabetes 9:392, 1960.
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