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May 4, 1940

TREATMENT OF CHRONIC ARTHRITIS: RESULTS OF VACCINE THERAPY WITH SALINE INJECTIONS USED AS CONTROLS

JAMA. 1940;114(18):1740-1742. doi:10.1001/jama.1940.02810180016005
Abstract

Despite years of experience in arthritis with vaccine therapy, given both subcutaneously and intravenously, difference of opinion still prevails regarding its value. This problem has been studied over a period of several years in the Arthritis Clinic of the Beth Israel Hospital. Our observations have been made in the past four years on a group of patients with chronic arthritis to whom vaccine therapy was given intravenously and physiologic solution of sodium chloride was given subcutaneously at weekly intervals.

Billings1 in 1912 emphasized the frequent presence of foci of infection in patients with chronic arthritis; subsequent investigators2 presented further evidence that chronic arthritis was due to a bacterial cause. Thus it has been reported that streptococci could be isolated from the blood, joints and distant foci of patients with chronic arthritis. Investigators3 have also found streptococcus precipitins, agglutinins and increased antistreptolysin content of blood serum in patients

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