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May 19, 1962

A Biochemical Basis of Multiple Sclerosis

JAMA. 1962;180(7):636. doi:10.1001/jama.1962.03050200120027

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


As stated by the author in his preface, the primary goal of this monograph is to develop a unified hypothesis capable of explaining the known facts about multiple sclerosis. The hypothesis, based on animal experimental and clinical observations made by the author over the past 12 years, and on observations reported in the literature, is that an important contributing factor to, if not the cause of, the lesions of multiple sclerosis is the consumption of excessive fat in the diet. According to the theory proposed, such fat ingestion leads to a harmful lipemia which upsets the suspension stability of the blood, thus resulting in sludge formation with scattered vascular obstructions, hypoxia, localized impairment of the blood-brain barrier, and perivascular demyelinated areas. Virtually all evidence derived from his own and others' experiments on the effect of high-fat meals and lipemia on the blood in animals and from the analysis of blood