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May 26, 1962

The Surgical Therapy of Acute Lead Encephalopathy

Author Affiliations


From the Cook County Children's Hospital and the Department of Pediatrics, University of Illinois College of Medicine.

JAMA. 1962;180(8):660-664. doi:10.1001/jama.1962.03050210022005

The encephalopathy that is seen in about 25% of all cases of lead poisoning in young children is a grave complication. In the space of 3 years in a county hospital, 101 children with this complication were treated. About one-third of the cases terminated in death. In many instances the diagnosis was made late, and there is no completely satisfactory therapy. In 25 cases with especially bad prognosis the medical treatment (urea as dehydrating and edathamil calcium-disodium as chelating agent) was supplemented with surgical treatment (flap craniectomy). One apparently moribund child was definitely rescued by surgical means, but 16 of the 25 died. No conclusion as to the place of surgery in the treatment of plumbemic encephalopathy was possible.

Greengard, J., et al.:  Lead Encephalopathy in Children: Intravenous Use of Urea in Its Management ,  New Engl J Med 264:1027 ( (May 18) ) 1961.Crossref
McLaurin, R. L., and Nichols, J. B., Jr.:  Extensive Cranial Decompression in Treatment of Severe Lead Encephalopathy ,  Pediatrics 20:653, 1957.
Bucy, P. C., and Buchanan, D. N.:  Simulation of Intracranial Tumor by Lead Encephalopathy in Children, with Remarks Concerning Surgical Treatment of Latter ,  JAMA 105:244 ( (July) ) 1935.Crossref
Haverfield, W. T.; Bucy, P. C.; and Elonen, A. S.:  Surgical Treatment of Lead Encephalopathy with Particular Reference to Prevention of Sequelae ,  JAMA 114:2432 ( (June) ) 1940.Crossref
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