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June 9, 1962


JAMA. 1962;180(10):832-833. doi:10.1001/jama.1962.03050230034012

The concept that the thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP) is due to antibodies to platelets is based on several observations: (1) the infants of mothers with this disease sometimes have a demonstable thrombocytopenia; (2) normal volunteers who are given infusions of platelets from patients with ITP sometimes develop thrombocytopenia; and (3) transfused platelets do not circulate as long in patients with ITP as they do in normal subjects. Corn and Upshaw, in a recent issue of the Archives of Internal Medicine, used a battery of testing procedures in attempts to demonstrate platelet antibodies in the serum of patients with ITP, in serum containing a platelet isoantibody, and in anti-human-platelet serum (AHPS) prepared by immunizing rabbits with human platelets. None of the methods of testing gave any indication of a platelet antibody in the serum of patients with ITP although rabbit AHPS invariably gave strongly positive results. Their

Corn, M., and Upshaw, J. D., Jr.:  Evaluation of Platelet Antibodies in Idiopathic Thrombocytopenic Purpura ,  Arch Intern Med 109:157 ( (Feb.) ) 1962.Crossref
Tullis, J. L.:  Role of Leukocyte and Platelet Antibody Tests in Management of Diverse Clinical Disorders ,  Ann Intern Med 54:1165-1180 ( (June) ) 1961.Crossref