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To the Editor:—
The contribution by Buckwalter and G. V. Tweed on "The Rhesus and MN Blood Groups and Disease," which appeared in The Journal (JAMA179:479 [Feb. 17] 1962) asserts that an association exists between the blood type N and rheumatic fever, and that individuals of particular Rh-Hr types are prone to duodenal and gastric ulceration, as well as to gastric carcinoma and rheumatic fever. These assertions can be challenged.Perusal of the tables suggests that a number of mistakes in blood grouping must have been made during this study, and, if this is true, this could have produced a bias in the results which created the illusion of the presence of various associations. As has been shown, in populations undergoing random intermarriage, the frequency of type MN cannot exceed 50%. Yet, in every study group by Buckwalter and Tweed, the frequency of type MN is significantly higher
Wiener AS. The Rhesus and MN Blood Groups and Disease. JAMA. 1962;180(11):988. doi:10.1001/jama.1962.03050240084024
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