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The malabsorption state in fibrocystic disease was studied by means of radioactive labeled triolein, oleic acid, and albumin. The effect of various pancreatic substitutes on fat absorption was determined. On a weight-for-weight basis lipancreatin appeared to be the most effective of the preparations tested. Twentyfour patients were treated for 6 to 24 months with good control of steatorrhea. Gain in weight and growth in height were comparable to the gains in weight and height of a group of normal children of same age and sex. The authors conclude that lipancreatin is a valuable adjunct for control of malabsorption in fibrocystic disease.
Haines RD, Hightower NC, Crozier WA, Eiband JM. Pancreatic Replacement Therapy in Fibrocystic Disease. JAMA. 1962;180(12):1000–1006. doi:10.1001/jama.1962.03050250006002
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