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June 23, 1962

Pancreatic Replacement Therapy in Fibrocystic Disease

Author Affiliations

Temple, Tex.

From the Departments of Medicine (Dr. Haines), Clinical Research (Dr. Hightower), and Pediatrics (Dr. Crozier), Scott and White Clinic, the Scott and White Memorial Hospital, and Scott, Sherwood, and Brindley Foundation (Dr. Eiband, Resident in Internal Medicine).

JAMA. 1962;180(12):1000-1006. doi:10.1001/jama.1962.03050250006002

The malabsorption state in fibrocystic disease was studied by means of radioactive labeled triolein, oleic acid, and albumin. The effect of various pancreatic substitutes on fat absorption was determined. On a weight-for-weight basis lipancreatin appeared to be the most effective of the preparations tested. Twentyfour patients were treated for 6 to 24 months with good control of steatorrhea. Gain in weight and growth in height were comparable to the gains in weight and height of a group of normal children of same age and sex. The authors conclude that lipancreatin is a valuable adjunct for control of malabsorption in fibrocystic disease.

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