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This Week in JAMA
August 1, 2012

This Week in JAMA

JAMA. 2012;308(5):427. doi:10.1001/jama.2012.3123

Depression is common in patients with heart failure. In a multicenter, randomized trial that involved 2322 patients with heart failure, Blumenthal and colleagues assessed the effect of aerobic exercise training—consisting of 3 months of supervised exercise followed by home exercise—on depressive symptoms and a composite outcome of death or hospitalization. The authors report that compared with guideline-based usual care, exercise training was associated with a moderate reduction in depressive symptoms and better clinical outcomes.


The safety and durability of endoscopic vein graft harvesting (EVH)—an alternative to incision-based open-vein graft harvesting—in coronary artery bypass graft (CABG) surgery has been called into question. Williams and colleagues compared long-term outcomes following the 2 procedures in 235 394 Medicare patients who underwent CABG surgery between 2003 and 2008. In analyses that adjusted for clinical characteristics, the authors found no difference in mortality or a composite outcome of death, myocardial infarction, and revascularization among patients having EVH or open-vein harvesting. In an editorial, Dacey discusses the safety of EVH in contemporary CABG surgery.