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Atherosclerosis-related vascular stiffness increases with age and is associated with hypertension. In an analysis of data from the 1759 participants in the Framingham Offspring study, Kaess and colleagues examined temporal relationships between blood pressure progression and 3 measures of vascular stiffness over 7 years of follow-up. The authors found that higher aortic stiffness—reflected by higher carotid-femoral pulse wave velocity, forward wave amplitude, and augmentation index—was associated with a higher risk of incident hypertension; however, initial blood pressure was not associated with progressive aortic stiffening. In an editorial, Mukherjee discusses whether vascular stiffness is a cause rather than an effect of hypertension.
This Week in JAMA. JAMA. 2012;308(9):839. doi:10.1001/jama.2012.3183
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