Customize your JAMA Network experience by selecting one or more topics from the list below.
Writing Group of the PREMIER Collaborative Research Group. Effects of Comprehensive Lifestyle Modification on Blood Pressure Control: Main Results of the PREMIER Clinical Trial. JAMA. 2003;289(16):2083–2093. doi:10.1001/jama.289.16.2083
Authors/Writing Group of the PREMIER Collaborative Research Group: Lawrence J. Appel, MD (chair), Departments of Medicine, Epidemiology, and International Health (Human Nutrition), Johns Hopkins Medical Institutions, Baltimore, Md; Catherine M. Champagne, PhD, and David W. Harsha, PhD, Pennington Biomedical Research Center, Baton Rouge, La; Lawton S. Cooper, MD, and Eva Obarzanek, PhD, National Heart, Lung, and Blood Institute, Bethesda, Md; Patricia J. Elmer, PhD, Victor J. Stevens, PhD, and William M. Vollmer, PhD, Kaiser Permanente Center for Health Research, Portland, Ore; Pao-Hwa Lin, PhD, and Laura P. Svetkey, MD, Duke Hypertension Center and Sarah W. Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, NC; and Deborah R. Young, PhD, Department of Kinesiology, University of Maryland, College Park.
Context Weight loss, sodium reduction, increased physical activity, and limited
alcohol intake are established recommendations that reduce blood pressure
(BP). The Dietary Approaches to Stop Hypertension (DASH) diet also lowers
BP. To date, no trial has evaluated the effects of simultaneously implementing
these lifestyle recommendations.
Objective To determine the effect on BP of 2 multicomponent, behavioral interventions.
Design, Setting, and Participants Randomized trial with enrollment at 4 clinical centers (January 2000-June
2001) among 810 adults (mean [SD] age, 50 [8.9] years; 62% women; 34% African
American) with above-optimal BP, including stage 1 hypertension (120-159 mm
Hg systolic and 80-95 mm Hg diastolic), and who were not taking antihypertensive
Intervention Participants were randomized to one of 3 intervention groups: (1) "established,"
a behavioral intervention that implemented established recommendations (n
= 268); (2) "established plus DASH,"which also implemented the DASH diet (n
= 269); and (3) an "advice only" comparison group (n = 273).
Main Outcome Measures Blood pressure measurement and hypertension status at 6 months.
Results Both behavioral interventions significantly reduced weight, improved
fitness, and lowered sodium intake. The established plus DASH intervention
also increased fruit, vegetable, and dairy intake. Across the groups, gradients
in BP and hypertensive status were evident. After subtracting change in advice
only, the mean net reduction in systolic BP was 3.7 mm Hg (P<.001) in the established group and 4.3 mm Hg (P<.001) in the established plus DASH group; the systolic BP difference
between the established and established plus DASH groups was 0.6 mm Hg (P = .43). Compared with the baseline hypertension prevalence
of 38%, the prevalence at 6 months was 26% in the advice only group, 17% in
the established group (P = .01 compared with the
advice only group), and 12% in the established plus DASH group (P<.001 compared with the advice only group; P = .12 compared with the established group). The prevalence of optimal
BP (<120 mm Hg systolic and <80 mm Hg diastolic) was 19% in the advice
only group, 30% in the established group (P = .005
compared with the advice only group), and 35% in the established plus DASH
group (P<.001 compared with the advice only group; P = .24 compared with the established group).
Conclusion Individuals with above-optimal BP, including stage 1 hypertension, can
make multiple lifestyle changes that lower BP and reduce their cardiovascular
Create a personal account or sign in to: