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Whether there are clinical consequences such as nosocomial infection, organ dysfunction, and death associated with prolonged storage of red blood cells for transfusion is not clear. In a randomized trial involving 377 premature infants who had birth weights of less than 1250 g and who required transfusion, Fergusson and colleagues found that compared with standard-issue red blood cells (mean age, 14.6 days), transfusion of fresh red blood cells (mean age, 5.1 days) was not associated with improvement in a composite outcome that included major neonatal morbidities and death.
Vigorous physical activity is thought to increase the risk of bleeding events in children with hemophilia. Broderick and colleagues assessed the risk in a case-crossover study that involved 104 children with moderate or severe hemophilia. The authors report that vigorous physical activity was associated with a moderate and transient relative increase in bleeding risk in the 8 hours following the activity; however, the absolute increase in bleeding risk is likely to be small. In an editorial, Manco-Johnson discusses risks and risk-reduction strategies for children with hemophilia who participate in vigorous, contact-related sports activities.
This Week in JAMA. JAMA. 2012;308(14):1403. doi:10.1001/jama.2012.3258
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