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This Week in JAMA
October 10, 2012

This Week in JAMA

JAMA. 2012;308(14):1403. doi:10.1001/jama.2012.3258

Whether there are clinical consequences such as nosocomial infection, organ dysfunction, and death associated with prolonged storage of red blood cells for transfusion is not clear. In a randomized trial involving 377 premature infants who had birth weights of less than 1250 g and who required transfusion, Fergusson and colleagues found that compared with standard-issue red blood cells (mean age, 14.6 days), transfusion of fresh red blood cells (mean age, 5.1 days) was not associated with improvement in a composite outcome that included major neonatal morbidities and death.

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Vigorous physical activity is thought to increase the risk of bleeding events in children with hemophilia. Broderick and colleagues assessed the risk in a case-crossover study that involved 104 children with moderate or severe hemophilia. The authors report that vigorous physical activity was associated with a moderate and transient relative increase in bleeding risk in the 8 hours following the activity; however, the absolute increase in bleeding risk is likely to be small. In an editorial, Manco-Johnson discusses risks and risk-reduction strategies for children with hemophilia who participate in vigorous, contact-related sports activities.

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