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High-dose micronutrient supplementation has been reported to reduce human immunodeficiency (HIV) disease progression and mortality among individuals not receiving highly active antiretroviral therapy (HAART). To assess the safety and efficacy of high-dose multivitamin supplementation in patients initiating HAART, Isanaka and colleagues randomly assigned 3418 Tanzanian patients to receive either high-dose or standard-dose oral supplements of vitamin B complex, vitamin C, and vitamin E. The authors report that high-dose multivitamin supplementation was not associated with a decrease in HIV disease progression or death and may increase alanine transaminase levels.
Carroll and colleagues examined trends in serum lipid levels among US adults in an analysis of data from 3 National Health and Nutrition Examination Surveys. Overall, the authors found favorable trends in lipids among US adults, including decreases in mean total cholesterol and low-density lipoprotein cholesterol levels and an increase in mean high-density lipoprotein cholesterol levels. Prevalence of lipid-lowering medication use increased significantly from 1988-2010.
This Week in JAMA. JAMA. 2012;308(15):1501. doi:10.1001/jama.2012.3273
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