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December 15, 1962

Value of Fibrinolysin in Management of Myocardial Infarction: A Preliminary Report

Author Affiliations

Bombay, India
Hon. Physician and Cardiologist, K.E.M. Hospital and G.S. Medical College, Hon. Cardiologist, Bombay Hospital (Dr. Datey), Senior Registrar, Department of Cardiology, K.E.M. Hospital (Dr. Hansoti). Dr. Hansoti is now Hon. Asst. Physician at J.J. Hospital, Bombay-8. Senior Medical Registrar, Department of Cardiology, K.E.M. Hospital, Bombay-12 (Dr. Pandya).

JAMA. 1962;182(11):1078-1081. doi:10.1001/jama.1962.03050500010003

Fibrinolysin was used in 15 cases of myocardial infarction to evaluate its efficacy. Treatment began within 24 hours after the onset in each case, and results were compared with those obtained previously without fibrinolysin in 40 consecutive patients. Fibrinolysin was given intravenously in doses of 50,000 to 150,-000 units in 250 ml. to 500 ml. of 5% dextrose over a period of 4 to 6 hours. In none of the cases was the pain relieved by fibrinolysin therapy. The 2 groups did not differ significantly as to temperature, blood pressure, intensity and duration of pain, or mortality rate. Within a few hours after fibrinolysin therapy was begun, however, 7 of the 15 patients showed remarkable electrocardiographic changes. The changes were interpreted as a greatly accelerated regression toward the normal which, in the patients treated without fibrinolysin, had taken 2 to 4 weeks.

Johnson, A. J., and Tillet, W. S.:  Lysis in Rabbits of Intravascular Blood Clots by Streptococcal Fibrinolytic System (Streptokinase) ,  J Exp Med 95:49, 1952.Crossref
Innerfield, I.; Angrist, A.; and Schwartz, A.:  Parenteral Administration of Trypsin—Clinical Effect in 538 Cases ,  JAMA 152:597, 1953.Crossref
Cliffton, E. E.; Grossi, C. E.; and Cannamela, D. A.:  Lysis of Thrombi Produced by Sodium Morrhuate in Femoral Vein of Dogs by Human Plasmin (Fibrinolysin) ,  Ann Surg 139:52, 1954.Crossref
Anlyan, W. G., et al.:  Fibrinolytic Agents in Surgical Practice ,  JAMA 175:290, 1961.Crossref
Ruegsegger, P., et al.:  Fibrinolytic (Plasmin) Therapy of Experimental Coronary Thrombi With Alteration of Evolution of Myocardial Infarction ,  Circulation 19:7, 1959.Crossref
Bolton, H. E., et al.:  Removal of Acute Coronary Thrombus With Fibrinolysin—In vivo Experiment ,  JAMA 175:307, 1961.Crossref
Nydick, I., et al.:  Salvage of Heart Muscle by Fibrinolytic Therapy After Experimental Coronary Occlusion ,  Amer Heart J 61:93, 1961.Crossref
Fletcher, A. P., and Sherry, S.:  Thrombolytic (Fibrinolytic) Therapy for Coronary Heart Disease ,  Circulation 22:619, 1960.Crossref
Cliffton, E. E.:  Angiology 10:244, 1959.Crossref
Dewar, H. A., and Horler, A. R.,  Brit Med J 2:671, 1961.Crossref
Sherry, S.; Fletcher, A. P.; and Alkjaersig, N.:  Fibrinolysis and Fibrinolytic Activity in Man ,  Physiol Rev 39:343, 1959.
Fletcher, A. P.; Alkjaersig, N.; and Sherry, S.:  Assay of Thrombolytic (Fibrinolytic) Mixtures Intended for Therapeutic Use ,  J Lab Clin Med 57:620, 1961.
Cliffton, E. E.:  Review of Clinical Experience With Clot-lysing Agents ,  Amer J Cardiol 6:476, 1960.Crossref
Moser, K. M.:  Thrombolysis With Fibrinolysin (Plasmin): New Therapeutic Approach to Thrombo-embolism ,  JAMA 167:1695, 1958.Crossref
de Leon, A. C., et al.:  Studies on Fibrinolytic System and Use of Fibrinolysin in Acute Myocardial Infarction: Preliminary Report ,  Circulation (abstract) 20:684, 1959.
Fletcher, A. P., et al.:  Maintenance of Sustained Thrombolytic State in Man: II Clinical Observations on Patients With Myocardial Infarction and Other Thromboembolic Disorders ,  J Clin Invest 3:1111, 1959.Crossref
Richter, I.H., et al.:  Experiences with Clot-Lysing Agents in Coronary Thrombosis ,  Amer J Cardiol 6:534, 1960.Crossref
Boucek, R.J., and Murphy, W.P.:  Segmental Perfusion of Coronary Arteries with Fibrinolysin in Man Following Myocardial Infarction ,  Amer J Cardiol 6:525, 1960.Crossref
Boyles, P.W.:  Laboratory Procedures and Therapy in Coronary Thrombosis ,  JAMA 175:279, 1961.Crossref
Dewar, H.A.; Horler, A.R.; and Cassells-Smith, A.J.:  Fibrinolytic Treatment of Coronary Thrombosis—A Pilot Study ,  Brit Med J 2:671, 1961.Crossref
Cliffton, E.E.:  Fibrinolysin as Agent for Treatment of Thrombo-Embolic Accidents ,  JAMA 175:302, 1961.Crossref
Massie, E., and Walsh, T.J.:  Clinical Vectorcardiography and Electrocardiography , Chicago: The Year Book Publisher Inc., 1960, p. 264.
Sodi-Pallares, D., and Calder, R.M.:  New Basis of Electrocardiography , St. Louis: C.V. Mosby Co., 1956, p. 202.
Horn, H., and Finkelstein, L.E.:  Arteriosclerosis of Coronary Arteries and Mechanism of Their Occlusion ,  Amer Heart J 19:655, 1940.Crossref
Nilsson, I.M.; Sjoerdsma, A.; and Waldenstrom, J.:  Antifibrinolytic Activity and Metabolism of Σ-Amino-Caproic in Man ,  Lancet 1:1322, 1960.Crossref