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Original Contribution
November 7, 2012

Intraoperative High-Dose Dexamethasone for Cardiac Surgery: A Randomized Controlled Trial

Author Affiliations

Author Affiliations: Division of Anesthesiology, Intensive Care, and Emergency Medicine, University Medical Center, Utrecht (Drs Dieleman, Moons, van Herwerden, Kalkman, and van Dijk and Ms Numan); Isala Klinieken, Zwolle (Dr Nierich); Amphia Ziekenhuis, Breda (Dr Rosseel); University Medical Center, Groningen (Dr van der Maaten); Erasmus Medical Center, Rotterdam (Dr Hofland); Medisch Spectrum Twente, Enschede (Dr Diephuis); Medical Center, Leeuwarden (Dr Schepp); Vrije Universiteit Medical Center, Amsterdam (Dr Boer); and Academic Medical Center, University of Amsterdam, Amsterdam (Dr Tijssen), the Netherlands.

JAMA. 2012;308(17):1761-1767. doi:10.1001/jama.2012.14144
Abstract

Context Prophylactic corticosteroids are often administered during cardiac surgery to attenuate the inflammatory response to cardiopulmonary bypass and surgical trauma; however, evidence that routine corticosteroid use can prevent major adverse events is lacking.

Objective To quantify the effect of intraoperative high-dose dexamethasone on the incidence of major adverse events in patients undergoing cardiac surgery.

Design, Setting, and Participants A multicenter, randomized, double-blind, placebo-controlled trial of 4494 patients aged 18 years or older undergoing cardiac surgery with cardiopulmonary bypass at 8 cardiac surgical centers in the Netherlands enrolled between April 13, 2006, and November 23, 2011.

Intervention Patients were randomly assigned to receive a single intraoperative dose of 1 mg/kg dexamethasone (n = 2239) or placebo (n = 2255).

Main Outcome Measures A composite of death, myocardial infarction, stroke, renal failure, or respiratory failure, within 30 days of randomization.

Results Of the 4494 patients who underwent randomization, 4482 (99.7%) could be evaluated for the primary outcome. A total of 157 patients (7.0%) in the dexamethasone group and 191 patients (8.5%) in the placebo group reached the primary study end point (relative risk, 0.83; 95% CI, 0.67-1.01; absolute risk reduction, −1.5%; 95% CI, −3.0% to 0.1%; P = .07). Dexamethasone was associated with reductions in postoperative infection, duration of postoperative mechanical ventilation, and lengths of intensive care unit and hospital stays. In contrast, dexamethasone was associated with higher postoperative glucose levels.

Conclusion In our trial of adults undergoing cardiac surgery, the use of intraoperative dexamethasone did not reduce the 30-day incidence of major adverse events compared with placebo.

Trial Registration clinicaltrials.gov Identifier: NCT00293592

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