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This Week in JAMA
January 9, 2013

This Week in JAMA

JAMA. 2013;309(2):111. doi:10.1001/jama.2012.145081

A continuous morphine infusion—standard postoperative analgesic therapy in infants—is associated with adverse effects such as respiratory depression. To examine whether intravenous paracetamol (acetaminophen) could reduce the postoperative morphine requirement, Ceelie and colleagues randomly assigned 71 infants who underwent major noncardiac surgery to postoperative continuous morphine or intermittent intravenous paracetamol—with rescue morphine administered to both groups as needed. The authors report that postoperative use of intravenous paracetamol was associated with a lower cumulative morphine dose in the first 48 postoperative hours. In an editorial, Anand discusses efficacy and safety of intravenous paracetamol in infants and children.

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To assess whether vitamin D supplementation might reduce symptoms and structural progression of knee osteoarthritis, McAlindon and colleagues randomly assigned 146 patients with symptomatic knee osteoarthritis to receive either oral cholecalciferol (2000 IU daily with dose escalation to achieve a target 25-hydroxyvitamin D serum level >36 ng/mL) or placebo for 2 years. The authors report that compared with placebo, vitamin D supplementation for 2 years did not reduce knee pain or cartilage volume loss.

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