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Approximately one-third of patients with peripheral artery disease (PAD) experience intermittent claudication and associated lifestyle limitations. In a randomized placebo-controlled trial involving 212 Australian patients with PAD, Ahimastos and colleagues found that compared with placebo, 24-week treatment with ramipril—an angiotensin-converting enzyme inhibitor—was associated with increased pain-free and maximum walking times during a standard treadmill exercise test and improvement in patient-perceived physical functioning. In an editorial, McDermott discusses medical therapy for PAD.
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To assess the efficacies of common treatments for chronic lateral epicondylalgia, Coombes and colleagues randomly assigned 165 patients to receive 1 of the following 4 treatments: corticosteroid injection, placebo injection, corticosteroid injection plus physiotherapy (PT), or placebo injection plus PT. The 2 primary trial outcomes were patient-reported complete recovery or much improvement assessed at 1 year and 1-year disease recurrence rates. The authors report that compared with placebo injection, corticosteroid injection resulted in lower rates of complete recovery/much improvement at 1 year, as well as greater recurrence. The PT and no-PT groups did not differ in 1-year ratings of complete recovery/much improvement or recurrence.
This Week in JAMA. JAMA. 2013;309(5):415. doi:10.1001/jama.2012.145196
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