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In a multicenter randomized trial that involved 1201 extremely preterm infants who were assigned to an oxygen therapy target of either 85% to 89% or 91% to 95% arterial oxygen saturation, Schmidt and colleagues found that targeting lower compared with higher oxygen saturations had no significant effect on the rate of death or disability at 18 months. In an editorial, Bancalari and Claure discuss oxygenation targets and outcomes in preterm infants.
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Young and colleagues examined the effect of early (within 4 days) vs late (after 10 days) tracheostomy in a multicenter randomized trial that enrolled 909 adult patients who had been mechanically ventilated for less than 4 days and were expected to require at least 7 additional days of ventilation. The authors report that tracheostomy within 4 days of initiating mechanical ventilation was not associated with improved 30-day mortality, the primary trial end point. In an editorial, Angus discusses the challenge of knowing when a mechanically ventilated patient should undergo tracheostomy.
This Week in JAMA. JAMA. 2013;309(20):2065. doi:10.1001/jama.2013.5769
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