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Research Letter
July 3, 2013

Smoking Cessation, Weight Change, and Coronary Heart Disease Among Postmenopausal Women With and Without Diabetes

Author Affiliations
  • 1Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington
  • 2National Heart, Lung, and Blood Institute, Bethesda, Maryland
  • 3HealthPartners Institute for Education and Research, Minneapolis, Minnesota
JAMA. 2013;310(1):94-96. doi:10.1001/jama.2013.6871

Cigarette smoking is an important cause of cardiovascular disease, and smoking cessation reduces the risk.1,2 However, weight gain after smoking cessation may increase the risk of diabetes and weaken the benefit of quitting.3 One study4 found an association between smoking cessation and a lower risk of cardiovascular events among participants without diabetes that was not modified by weight gain. However, this study4 had limited power for participants with diabetes and the more specific outcome of coronary heart disease (CHD). We used data from the Women’s Health Initiative (WHI)5 to assess the association between smoking cessation, weight gain, and subsequent CHD risk among postmenopausal women with and without diabetes.