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In a randomized trial that enrolled 60 treatment-naive patients with hepatitis C virus (HCV)
genotype 1 infection—including those with unfavorable treatment characteristics such as black
race, genotype 1a, advanced liver fibrosis, and obesity—Osinusi and colleagues assessed the
effect of treatment with sofosbuvir in combination with ribavirin on sustained virologic
response—defined as an undetectable HCV viral load assessed 24 weeks after treatment
completion. The authors report that a 24-week regimen of sofosbuvir and weight-based or low-dose
ribavirin resulted in sustained viral response rates of 68% and 48%, respectively.
Author Video Interview
Difficulties identifying biliary anatomy during cholecystectomy can result in duct injury. To
examine whether routine intraoperative cholangiography can prevent common duct injury during
cholecystectomy, Sheffield and colleagues analyzed data from 92 932 Texas Medicare beneficiaries who
underwent cholecystectomy in 2000-2009. Using instrumental variable analysis, with percentage of
intraoperative cholangiography use by hospital and surgeon as the instrumental variables, the
authors found no association between intraoperative cholangiography and common duct injury. In an
Editorial, Bilimoria and colleagues discuss the use of instrumental variable analysis to address
unmeasured confounding in analyses of observational data.
Highlights. JAMA. 2013;310(8):767–769. doi:10.1001/jama.2013.5273
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