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In This Issue of JAMA
August 28, 2013


JAMA. 2013;310(8):767-769. doi:10.1001/jama.2013.5273

In a randomized trial that enrolled 60 treatment-naive patients with hepatitis C virus (HCV) genotype 1 infection—including those with unfavorable treatment characteristics such as black race, genotype 1a, advanced liver fibrosis, and obesity—Osinusi and colleagues assessed the effect of treatment with sofosbuvir in combination with ribavirin on sustained virologic response—defined as an undetectable HCV viral load assessed 24 weeks after treatment completion. The authors report that a 24-week regimen of sofosbuvir and weight-based or low-dose ribavirin resulted in sustained viral response rates of 68% and 48%, respectively.

Author Video Interview

Difficulties identifying biliary anatomy during cholecystectomy can result in duct injury. To examine whether routine intraoperative cholangiography can prevent common duct injury during cholecystectomy, Sheffield and colleagues analyzed data from 92 932 Texas Medicare beneficiaries who underwent cholecystectomy in 2000-2009. Using instrumental variable analysis, with percentage of intraoperative cholangiography use by hospital and surgeon as the instrumental variables, the authors found no association between intraoperative cholangiography and common duct injury. In an Editorial, Bilimoria and colleagues discuss the use of instrumental variable analysis to address unmeasured confounding in analyses of observational data.