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Research Letter
November 6, 2013

Autoantibodies Present Before Symptom Onset in Primary Sjögren Syndrome

Author Affiliations
  • 1Broegelmann Research Laboratory, University of Bergen, Bergen, Norway
  • 2Department of Rheumatology, Lund University, Malmö, Sweden
  • 3Department of Laboratory Medicine Malmö, Lund University, Malmö, Sweden
JAMA. 2013;310(17):1854-1855. doi:10.1001/jama.2013.278448

Autoantibodies are characteristic of primary Sjögren syndrome1 and may be involved in its pathogenesis.2 We investigated autoantibodies present before symptom onset in patients with Sjögren syndrome because data on this issue are limited.

All patients with primary Sjögren syndrome at Malmö University Hospital (Malmö, Sweden) have been included in a registry since 1984.3 To obtain presymptomatic serum samples, the registry was linked with 3 biobanks containing specimens from 625 000 individuals submitted for microbiological analyses or population-based studies of healthy individuals.4

Date of symptom onset was determined retrospectively from the patient during the first office visit at which Sjögren syndrome was diagnosed. All cases provided written informed consent at inclusion in the registry. The study was approved by the ethics committee at Lund University.

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