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In This Issue of JAMA
December 25, 2013


JAMA. 2013;310(24):2587-2589. doi:10.1001/jama.2013.5481

Treatment of pediatric migraine is challenging and often not evidence-based. Powers and colleagues randomly assigned 135 children and adolescents with chronic migraine to receive 10 sessions of cognitive behavioral therapy (CBT) or headache education—in combination with amitriptyline, a common prophylactic medication for migraine—and found that CBT plus amitriptyline was superior to headache education plus amitriptyline in reducing headache days and migraine-related disability. In an Editorial, Connelly discusses challenges to implementation of CBT in the treatment of chronic migraine in children and adolescents.

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Author Video Interview

Animal studies suggest that mobilization of bone marrow progenitor cells improves perfusion of an ischemic limb. To investigate whether progenitor cell mobilization improves exercise capacity in patients with peripheral artery disease, Poole and colleagues randomly assigned 159 patients with intermittent claudication to receive injections of granulocyte-macrophage colony-stimulating factor (GM-CSF) or placebo for 4 weeks. The authors report that compared with placebo, GM-CSF therapy did not improve peak treadmill walking time at a 3-month follow-up.