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This Week in JAMA
March 19, 2008

This Week in JAMA

JAMA. 2008;299(11):1225. doi:10.1001/jama.299.11.1225


Edited by Catherine D. DeAngelis, MD, MPH, Phil B. Fontanarosa, MD, MBA, and Boris Pasche, MD, PhD

Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties. In patients undergoing diagnostic coronary angiography, Bhattacharyya and colleagues investigated the relationship between PON1 genotypes and their functional activity with measures of oxidative stress and CVD risk. The authors found that PON1 gene polymorphisms were associated with low levels of PON1 activity, increased levels of markers of oxidative stress, and increased risks of prevalent CVD and adverse cardiac events.


In a prospective multicenter study involving 37 534 European patients, van Meurs and colleagues examined the association of 2 common variants of the low-density lipoprotein receptor–related protein 5 (LRP5) gene and 1 variant of the LRP6 gene with bone mineral density (BMD) and fracture risk. The authors found that the 2 LRP5 gene variants were consistently associated with BMD and fracture risk.