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Assessments of the relationship between dietary supplementation with folic acid, B vitamins, or both and cardiovascular disease (CVD) risk have been inconclusive. Albert and colleagues Article report results of the randomized, placebo-controlled Women's Antioxidant and Folic Acid Cardiovascular Study, which tested whether a combination of folic acid, vitamin B6 and vitamin B12 would reduce CVD events among women at high risk of CVD. The authors found that although vitamin treatment was associated with significant reductions in homocysteine levels, there was no difference in the risk of CVD events among women in either the vitamin or placebo groups during 7.3 years of follow-up. In an editorial, Lonn Article discusses possible reasons that clinical benefits have not been realized in randomized trials of B vitamin supplementation for CVD prevention.
This Week in JAMA . JAMA. 2008;299(17):1989. doi:10.1001/jama.299.17.1989
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