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A JAMA THEME ISSUE
Edited by Jeanette M. Smith, MD, and Gianna Zuccotti, MD, MPH
Antiretroviral therapy can be associated with visceral adiposity and metabolic complications, possibly caused by growth hormone (GH) deficiency. In a randomized trial, Lo and colleagues assessed the effects of low-dose GH vs placebo on body composition and cardiovascular disease markers among patients with HIV-associated abdominal obesity. The authors found that patients receiving GH experienced significant reductions in visceral fat, truncal obesity, triglycerides, and diastolic blood pressure but experienced an increase in 2-hour postchallenge glucose levels.
To assess the incidence of HIV infection in the United States, Hall and colleagues applied an algorithm that combines HIV-antibody testing and the BED HIV-1 capture enzyme immunoassay—which distinguishes recent from long-standing infections—to serum specimens from patients 13 years or older, who resided in 22 states and who were diagnosed in 2006. The authors estimate that there were 56 300 (95% confidence interval, 48 200-64 500) new HIV infections in 2006, which were disproportionately concentrated among men who have sex with men and among African Americans.
This Week in JAMA . JAMA. 2008;300(5):475. doi:10.1001/jama.300.5.475
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