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This Week in JAMA
November 19, 2008

This Week in JAMA

JAMA. 2008;300(19):2213. doi:10.1001/jama.2008.685

The herb Ginkgo biloba is popularly claimed to have beneficial effects on memory and cognition, but evidence that it is effective for the primary prevention of dementia is lacking. In the Ginkgo Evaluation of Memory Study, 3069 older adults with normal cognition or mild cognitive impairment at baseline were randomly assigned to receive either G biloba or placebo and were assessed every 6 months for incident dementia. DeKosky and colleagues Article report that G biloba had no effect on the incidence of dementia or Alzheimer disease during a median follow-up of 6.1 years. In an editorial, Schneider Article discusses the lack of evidence that G biloba will prevent cognitive decline and dementia in elderly adults.