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November 26, 2008

Incorrect Risk Cited in: Prenatal Genome Testing Sparks Debate

JAMA. 2008;300(20):2370. doi:10.1001/jama.300.20.2370

Incorrect Risk: In the Medical News & Perspectives article entitled “Prenatal Genome Testing Sparks Debate” published in the October 8, 2008, issue of JAMA (2008;300[14]:1637-1639), the magnitude of risk of developing schizophrenia associated with certain copy number variations was miscited. On page 1638, in the second column, in the last paragraph, the second sentence should read, “For example, he noted that a pair of genetic association studies published in late July identified 3 rare copy variations that are associated with an increased risk of schizophrenia. One of the studies linked deletions at 1q21.1, 15q11.2, and 15q13.3 with a significantly increased risk of developing schizophrenia with odds ratios of 14.83, 2.73, and 11.54, respectively (Stefansson H et al. Nature. 2008;455[7210]:232-236) and the second study linked deletions at 1q21.1, 15q13.3, and 22q11.2 with a significantly increased risk of developing the disorder with odds ratios of 6.6, 17.9, and 21.6, respectively (International Schizophrenia Consortium. Nature. 2008;455[7210]:237-241).”