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Findings to advance understanding of the genetics and pathobiology of gliomas are reported in 2 articles in this issue. In the first article, Bredel and colleagues Article report results of multidimensional genomic and clinical profiling of 501 gliomas. The authors found a consistent pattern of nonrandom chromosomal alterations that involved multiple genes. In addition, the authors confirmed their hypothesis that these genetic alterations act synergistically to facilitate glioma development and progression and are associated with patient prognosis. In the second article, Yadav and colleagues Article examined the functional relationship between 2 of these interacting genes in glioblastomas—annexin A7 (ANXA7; a potential tumor suppressor gene) and epidermal growth factor receptor (EGRF). The authors found that heterozygous ANXA7 gene deletion is associated with an increase in EGRF expression, enhanced tumorigenicity, and poor survival of patients with glioblastomas. In an editorial, Pasche and Myers Article discuss potential clinical implications of these findings.
This Week in JAMA . JAMA. 2009;302(3):227. doi:https://doi.org/10.1001/jama.2009.1031
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